Results 91 to 100 of about 7,431,248 (353)
Numerical methodology for analyses of tubular KK multiplanar steel joints
REM: International Engineering JournalHerein is presented a numerical methodology for a static resistance analysis of symmetrically loaded multiplanar KK joints in circular hollow steel sections.
Nádia Cazarim da Silva Forti +2 more
doaj +1 more source
, 2017 REINFORCED CONCRETE (RC) BEAM-COLUMN CONNECTIONS ESPECIALLY THOSE WITHOUT TRANSVERSE REINFORCEMENT IN JOINT REGION CAN EXHIBIT BRITTLE BEHAVIOR WHEN INTENSIVE DAMAGE IS CONCENTRATED IN THE JOINT REGION DURING AN EARTHQUAKE EVENT.
M. A. Najafgholipour +3 more
semanticscholar +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Governing failure mode of unsaturated soil slopes under rainwater infiltration
E3S Web of Conferences, 2016 Due to rainwater infiltration and loss of matric suction above the wetting font, both translational and rotational slips may occur in an unsaturated soil slope. It is useful to know which failure mode is more critical.
Huang Wengui +2 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Procedure for Failure Mode, Effects, and Criticality Analysis (FMECA) [PDF]
This document provides guidelines for the accomplishment of Failure Mode, Effects, and Criticality Analysis (FMECA) on the Apollo program. It is a procedure for analysis of hardware items to determine those items contributing most to system unreliability
core +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Chengshi guidao jiaotong yanjiuObjective Under the DRB (driverless return button) mode on Xi’an Metro Line 14, the train emergency braking will occur after the train automatically switching its head car on the turn-back line, resulting in the train turn-back failure.
FANG Jiewei
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Renmin Zhujiang, 2020 Deformation and failure of rock slope are mainly controlled by structural planes developed in rock mass. The stereographic projection method is used to analyze the failure modes of rock slope, which can easily determine the combination relationship ...
KANG Zhiliang +4 more
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