Results 101 to 110 of about 1,659,508 (308)

Evaluation of in-plane shear failure in composite laminate with high percentage of 90o plies [PDF]

The first step in analysis composite joint is to have a correct and appropriate definition of properties of material used. The effect of fibre orientation and the interaction between them in the laminated composite play a key role in determining the ...
Noroozi, Siamak, Vali-Shariatpanahi, Sepideh, Vinney, John   +2 more
core  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The Reliability of a Tunnel Boring Machine [PDF]

Greater levels of complexity in tunnelling with Tunnel Boring Machine (TBM) allow higher chances of fail-ures that may increase the potential hazardous risks. This paper presents the results of a study on TBM reliability using risk analysis.
جعفری, محمدجواد, قراری, نورالدین   +1 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Microstructure-failure mode correlations in braided composites [PDF]

Explication of the fracture processes of braided composites is needed for modeling their behavior. Described is a systematic exploration of the relationship between microstructure, loading mode, and micro-failure mechanisms in carbon/epoxy braided ...
El-Shiekh, Aly, Filatovs, G. J., Sadler, Robert L.   +2 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

DISTANCIAS A LOS EXTREMOS EN CONEXIONES PERNADAS DE MADERA

Revista EIA
En este artículo se estudia la influencia de las distancias a los extremos en la aparición de concentraciones de tensiones en las conexiones pernadas de madera.
Beatriz Adela Echavarría López, César Augusto Echavarría López   +1 more
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Research on the Punching Shear Performance of Steel Grid–UHPC Composite Bridge Decks

Buildings
This study conducted punching shear tests on steel grid–ultra-high-performance concrete (UHPC) composite bridge decks and performed finite element analysis (FEA) to evaluate their punching shear performance. Initially, a comparative analysis is conducted
Sumei Liu, Peng Wang, Pengfei Ren, Hanshan Ding   +3 more
doaj   +1 more source