Results 31 to 40 of about 1,659,508 (308)
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa +3 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Effects of stitching on delamination of satin weave carbon-epoxy laminates under mode I, mode II and mixed-mode I/II loadings [PDF]
, 2010 The objective of the present study is to characterize the effect of modified chain stitching on the delamination growth under mixed-mode I/II loading conditions.
AJ Kinloch +22 more
core +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Advances in Civil Engineering, 2020 An experimental study of a rock-like material containing a preexisting fissure subjected to loading and unloading triaxial compression is carried out, and the results show that the mechanical characteristics of the rock-like specimen depend heavily on ...
Taoli Xiao, Mei Huang, Min Gao
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Annals of Glaciology, 2020 Sea ice is composed of columnar-shaped grains. To investigate the influence of the loading direction on the uniaxial compressive strength and failure processes of sea ice, field experiments were performed with first-year level ice.
Shunying Ji, Xiaodong Chen, Anliang Wang
doaj +1 more source
The impact of diversity upon common mode failures [PDF]
, 1996 Recent models for the failure behaviour of systems involving redundancy and diversity have shown that common mode failures can be accounted for in terms of the variability of the failure probability of components over operational environments.
Littlewood, B.
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Potential Failure Mode Analysis
, 2021 Identification, description, and evaluation of site-specific potential failure modes (PFMs) are the most important steps towards a risk analysis. Potential failure mode analysis (PFMA) is a standard and state-of-the-practice technique in dam engineering and forms the basis for risk evaluations and event tree development. Figure 27.1 illustrates the key
Victor E. Saouma +1 more
+5 more sources