Results 51 to 60 of about 1,671,563 (312)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Failure mode analysis of the Endologix endograft [PDF]

Journal of Vascular Surgery, 2015
Type III (T-III) endoleaks following endovascular aneurysm repair (EVAR) remain a major concern. Our center experienced a recent concentration of T-III endoleaks requiring elective and emergency treatment and prompted our review of all EVAR implants over a 40-month period from April 2011 until August 2014.
Lemmon, Gary W., Motaganahalli, Rahgu L., Chang, Tiffany, Slaven, James, Aumiller, Ben, Kim, Bradford J., Dalsing, Michael C.   +6 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Comparative study of the effects of different nanomaterials on the failure process of saturated concrete in an underground reservoir of a coal mine

Energy Exploration & Exploitation, 2022
The macroscopic failure of concrete used to form an artificial dam in an underground coal mine reservoir is the final manifestation of crack propagation and penetration: the mode of crack propagation is key to the safety evaluation of concrete structures.
Xianjie Hao, Yingnan Wei, Tong Zhang, Zeyu Chen, Cun Zhang, Teng Teng   +5 more
doaj   +1 more source

Validation of low velocity impact modelling on different stacking sequences of CFRP laminates and influence of fibre failure [PDF]

, 2013
This paper presents a validation of low-velocity impact Finite Element (FE) modelling. Based on switching ply location of reference layup [02,452,902,-452]s T700GC/M21 laminated plates from Bouvet et al.
Bouvet, Christophe, Hongkarnjanakul, Natthawat, Rivallant, Samuel   +2 more
core   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Research on the Failure Mode of Buried Pipeline under Impact Load

Shiyou jixie, 2020
In order to understand the failure modes of pipelines under different parameters, The numerical model established by the finite element software ABAQUS is used to simulate and calculate the plastic region distribution, peak stress and deformation of ...
白冰洁, 黄子川, 杜国峰
doaj  

Study on Mechanical Properties and Cracking Mode of Coal Samples under Compression–Shear Coupled Load Considering the Effect of Loading Rate

Applied Sciences, 2020
Under coupled compression–shear loading, the failure and instability behavior of inclined pillars is different from that of horizontal pillars. To enhance the reliability and accuracy of pillar strength design, the influence of different inclination ...
Yanlong Chen, Huidong Cui, Hai Pu, Peng Wu, Liang Chen, Kai Zhang   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source