Results 51 to 60 of about 395,957 (267)

Study on Mechanical Properties and Cracking Mode of Coal Samples under Compression–Shear Coupled Load Considering the Effect of Loading Rate

Applied Sciences, 2020
Under coupled compression–shear loading, the failure and instability behavior of inclined pillars is different from that of horizontal pillars. To enhance the reliability and accuracy of pillar strength design, the influence of different inclination ...
Yanlong Chen, Huidong Cui, Hai Pu, Peng Wu, Liang Chen, Kai Zhang   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Investigation on ultimate strength of thin wall tee pipe for sodium cooled fast reactor under seismic loading

Mechanical Engineering Journal, 2016
It is important to investigate the failure mode and ultimate strength of piping components in order to evaluate the seismic integrity of piping. Many failure tests of thick wall and high pressure piping for Light Water Reactors (LWRs) have been ...
Tomoyoshi WATAKABE, Kazuyuki TSUKIMORI, Akihito OTANI, Makoto MORIIZUMI, Naoaki KANEKO   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Uniaxial Compression Test and Numerical Study on the Mechanical Mechanism of Crack Exhibition and Propagation in Layered Rocks

Applied Sciences
Layered rocks are widely distributed in mining and underground engineering. The evolution processes, such as crack initiation, development and penetration, inevitably occur due to stress changes.
Zhengnan Zhang, Xiangxin Liu, Bin Gong, Zhengzhao Liang, Xianxian Liu, Xun You   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

An Improved Fracture Criterion for Mixed-Mode Delamination in Composite Materials

Aerospace Research Communications
Delamination is a common failure mode in laminated composites, usually under I/II mixed-mode loading. This paper incorporates the influence of mixed-mode ratio on the critical distance in the fracture criterion based on the minimum strain energy density ...
Xinyuan Chen, Chengce Yuan, Wei Zhang, Wei Zhang, Weiqiu Chen, Weiqiu Chen, Weiqiu Chen   +6 more
doaj   +1 more source