Results 61 to 70 of about 4,249,486 (246)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Development of a Finite Element Methodology for Modelling Mixed-Mode Delamination Growth [PDF]

, 2007
A critical failure mechanism for composite skin-stiffened structures in compression is separation of the skin and stiffener, which can be considered analogous to interlaminar cracking.
Degenhardt, Richard, Bayandor, J., Thomson, R.S., Orifici, Adrian, Büsing, S.   +4 more
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Failure mode type.

, 2023
a) Titanium base abutment show failure mode Type1, cement remained on the abutment surface >90%, b) Titanium base abutment show failure mode Type2, cement remain on the abutment between 10–90%; c) Titanium base abutment show failure mode Type3, cement ...
Rawikorn Krongvanitchayakul (17283545), Chatchai Kunavisarut (9375036)   +1 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Uniaxial Compression Test and Numerical Study on the Mechanical Mechanism of Crack Exhibition and Propagation in Layered Rocks

Applied Sciences
Layered rocks are widely distributed in mining and underground engineering. The evolution processes, such as crack initiation, development and penetration, inevitably occur due to stress changes.
Zhengnan Zhang, Xiangxin Liu, Bin Gong, Zhengzhao Liang, Xianxian Liu, Xun You   +5 more
doaj   +1 more source

Investigation on ultimate strength of thin wall tee pipe for sodium cooled fast reactor under seismic loading

Mechanical Engineering Journal, 2016
It is important to investigate the failure mode and ultimate strength of piping components in order to evaluate the seismic integrity of piping. Many failure tests of thick wall and high pressure piping for Light Water Reactors (LWRs) have been ...
Tomoyoshi WATAKABE, Kazuyuki TSUKIMORI, Akihito OTANI, Makoto MORIIZUMI, Naoaki KANEKO   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

An Improved Fracture Criterion for Mixed-Mode Delamination in Composite Materials

Aerospace Research Communications
Delamination is a common failure mode in laminated composites, usually under I/II mixed-mode loading. This paper incorporates the influence of mixed-mode ratio on the critical distance in the fracture criterion based on the minimum strain energy density ...
Xinyuan Chen, Chengce Yuan, Wei Zhang, Wei Zhang, Weiqiu Chen, Weiqiu Chen, Weiqiu Chen   +6 more
doaj   +1 more source