Results 61 to 70 of about 395,957 (267)

Numerical and experimental study on failure behavior of steel-aluminium mechanical clinched joints under multiple test conditions

open access: yesInternational Journal of Lightweight Materials and Manufacture, 2019
In this work, the numerical and experimental study was performed to explore the mechanical properties and failure behavior of steel-aluminium mechanical clinched joints under multiple test conditions.
Yanli Song   +4 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Numerical methodology for analyses of tubular KK multiplanar steel joints

open access: yesREM: International Engineering Journal
Herein is presented a numerical methodology for a static resistance analysis of symmetrically loaded multiplanar KK joints in circular hollow steel sections.
Nádia Cazarim da Silva Forti   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Causes and Countermeasures of Train Emergency Braking Failures under DRB Turn-back Mode on Xi’an Metro Line 14

open access: yesChengshi guidao jiaotong yanjiu
Objective Under the DRB (driverless return button) mode on Xi’an Metro Line 14, the train emergency braking will occur after the train automatically switching its head car on the turn-back line, resulting in the train turn-back failure.
FANG Jiewei
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Governing failure mode of unsaturated soil slopes under rainwater infiltration

open access: yesE3S Web of Conferences, 2016
Due to rainwater infiltration and loss of matric suction above the wetting font, both translational and rotational slips may occur in an unsaturated soil slope. It is useful to know which failure mode is more critical.
Huang Wengui   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Recognition of Failure Mode of Slope Block Failure Mode in Zhouning Pumped Storage Station Based on Stereographic Projection Method

open access: yesRenmin Zhujiang, 2020
Deformation and failure of rock slope are mainly controlled by structural planes developed in rock mass. The stereographic projection method is used to analyze the failure modes of rock slope, which can easily determine the combination relationship ...
KANG Zhiliang   +4 more
doaj  

Home - About - Disclaimer - Privacy