Results 71 to 80 of about 7,431,248 (353)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Mechanical Engineering Journal, 2016 It is important to investigate the failure mode and ultimate strength of piping components in order to evaluate the seismic integrity of piping. Many failure tests of thick wall and high pressure piping for Light Water Reactors (LWRs) have been ...
Tomoyoshi WATAKABE +4 more
doaj +1 more source
Failure-mode-hierarchy-based design for reinforced concrete structures [PDF]
, 2005 Innovations in concrete construction can be held back by the inability of codes of practice to accommodate new materials. The current design and safety philosophy (DSP) of reinforced concrete relies heavily on the properties of steel reinforcement.
Guadagnini, M. +2 more
core +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Mixed-mode cyclic debonding of adhesively bonded composite joints [PDF]
A combined experimental-analytical investigation to characterize the cyclic failure mechanism of a simple composite-to-composite bonded joint is conducted.
Mall, S., Rezaizadeh, M. A.
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Applied SciencesLayered rocks are widely distributed in mining and underground engineering. The evolution processes, such as crack initiation, development and penetration, inevitably occur due to stress changes.
Zhengnan Zhang +5 more
doaj +1 more source
New risk assessment and prioritization failure modes based approach in a gas turbine system [PDF]
, 2022 Ammar Chakhrit +7 more
openalex +1 more source
Tensile failure criteria for fiber composite materials [PDF]
The analysis provides insight into the failure mechanics of these materials and defines criteria which serve as tools for preliminary design material selection and for material reliability assessment. The model incorporates both dispersed and propagation
Rosen, B. W., Zweben, C. H.
core +1 more source