Results 71 to 80 of about 1,659,508 (308)

Mixed-mode cyclic debonding of adhesively bonded composite joints [PDF]

A combined experimental-analytical investigation to characterize the cyclic failure mechanism of a simple composite-to-composite bonded joint is conducted.
Mall, S., Rezaizadeh, M. A.
core   +1 more source

New method for critical failure prediction of complex systems [PDF]

, 1968
Rigorous analytical technique, called criticality determination methodology /or CD technique/ determines the probability that a given complex system will successfully achieve stated objectives.
Cox, C. T., Eagle, K. H., Malik, D. F., Wolin, S.   +3 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Sounding rocket reliability reassessment [PDF]

Sounding rocket reliability - failure ...
Hisler, A.
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Numerical and experimental study on failure behavior of steel-aluminium mechanical clinched joints under multiple test conditions

International Journal of Lightweight Materials and Manufacture, 2019
In this work, the numerical and experimental study was performed to explore the mechanical properties and failure behavior of steel-aluminium mechanical clinched joints under multiple test conditions.
Yanli Song, Lulu Yang, Genpeng Zhu, Lin Hua, Runze Liu   +4 more
doaj   +1 more source

Lifetime evaluation of concrete structures under sustained post-peak loading [PDF]

, 2005
Experimental tests on crack propagation in concrete under constant post-peak loading are simulated using the finite element method and the cohesive crack model, in both Mode I and Mixed-mode conditions.
Barpi, Fabrizio, Valente, Silvio
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

An Improved Fracture Criterion for Mixed-Mode Delamination in Composite Materials

Aerospace Research Communications
Delamination is a common failure mode in laminated composites, usually under I/II mixed-mode loading. This paper incorporates the influence of mixed-mode ratio on the critical distance in the fracture criterion based on the minimum strain energy density ...
Xinyuan Chen, Chengce Yuan, Wei Zhang, Wei Zhang, Weiqiu Chen, Weiqiu Chen, Weiqiu Chen   +6 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source