Results 81 to 90 of about 1,659,508 (308)
Numerical methodology for analyses of tubular KK multiplanar steel joints
REM: International Engineering JournalHerein is presented a numerical methodology for a static resistance analysis of symmetrically loaded multiplanar KK joints in circular hollow steel sections.
Nádia Cazarim da Silva Forti +2 more
doaj +1 more source
Patent Reform and Best Mode: A Signal to the Patent Office or a Step Toward Elimination? [PDF]
, 2012 On September 16, 2011, President Obama signed the America Invents Act (AIA), the first major overhaul of the patent system in nearly sixty years. This article analyzes the recent change to patent law\u27s best mode requirement under the AIA.
Vacca, Ryan G.
core +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Governing failure mode of unsaturated soil slopes under rainwater infiltration
E3S Web of Conferences, 2016 Due to rainwater infiltration and loss of matric suction above the wetting font, both translational and rotational slips may occur in an unsaturated soil slope. It is useful to know which failure mode is more critical.
Huang Wengui +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
FMEA of gasketed and non-gasketed bolted flanged pipe joints [PDF]
, 2005 Limited work is available in the literature on the Failure Mode and Effects Analysis of bolted flanged pipe joints. From previous comparative reliability studies of both gasketed and non-gasketed bolted flanged pipe joints, generally it is found that ...
Abid, Muhammad, Nash, David
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Chengshi guidao jiaotong yanjiuObjective Under the DRB (driverless return button) mode on Xi’an Metro Line 14, the train emergency braking will occur after the train automatically switching its head car on the turn-back line, resulting in the train turn-back failure.
FANG Jiewei
doaj +1 more source
A compressive failure model for anisotropic plates with a cutout under compressive and shear loads [PDF]
Failure models for the prediction of compressive strength of plates with a hole are investigated. One of the models is based on the strength failure of the fibers that leads to fiber kinking failure. A different version is developed for cases where shear
Guerdal, Zafer, Haftka, Raphael T.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source