Results 81 to 90 of about 7,431,248 (353)

New method for critical failure prediction of complex systems [PDF]

, 1968
Rigorous analytical technique, called criticality determination methodology /or CD technique/ determines the probability that a given complex system will successfully achieve stated objectives.
Cox, C. T., Eagle, K. H., Malik, D. F., Wolin, S.   +3 more
core   +1 more source

A new approach for evaluation of risk priorities of failure modes in FMEA [PDF]

, 2001
This paper presents a method for carrying out the calculus of the risk priority of failures in Failure Mode and Effect Analysis (FMEA). The novelty of the method consists of new management of data provided by the design team, normally given on ...
Franceschini, Fiorenzo, Galetto, Maurizio   +1 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Numerical and experimental study on failure behavior of steel-aluminium mechanical clinched joints under multiple test conditions

International Journal of Lightweight Materials and Manufacture, 2019
In this work, the numerical and experimental study was performed to explore the mechanical properties and failure behavior of steel-aluminium mechanical clinched joints under multiple test conditions.
Yanli Song, Lulu Yang, Genpeng Zhu, Lin Hua, Runze Liu   +4 more
doaj   +1 more source

Failure Mode and Effect Analysis Implementation for Spare Part Classification and Inventory Management in Automotive Manufacturing (Case Study of Pt. XYZ)

, 2022
Sudarmaji Saroji, Ahmad Hidayat Sutawijaya   +1 more
openalex   +1 more source

Analysis of System-Failure Rate Caused by Soft-Errors using a UML-Based Systematic Methodology in an SoC [PDF]

, 2007
This paper proposes an analytical method to assess the soft-error rate (SER) in the early stages of a System-on-Chip (SoC) platform-based design methodology.
Benso, Alfredo, Di Carlo, Stefano, Di Natale, Giorgio, Hosseinabady, M., Navabi, Z., Neishaburi, M.H., Prinetto, Paolo Ernesto   +6 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

An Improved Fracture Criterion for Mixed-Mode Delamination in Composite Materials

Aerospace Research Communications
Delamination is a common failure mode in laminated composites, usually under I/II mixed-mode loading. This paper incorporates the influence of mixed-mode ratio on the critical distance in the fracture criterion based on the minimum strain energy density ...
Xinyuan Chen, Chengce Yuan, Wei Zhang, Wei Zhang, Weiqiu Chen, Weiqiu Chen, Weiqiu Chen   +6 more
doaj   +1 more source

Sounding rocket reliability reassessment [PDF]

Sounding rocket reliability - failure ...
Hisler, A.
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source