Results 111 to 120 of about 1,270,105 (343)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

USULAN PENERAPAN LEAN SIX SIGMA, FMEA DAN FUZZY UNTUK MENINGKATKAN KUALITAS PRODUK BOTOL SABUN CAIR

Journal of Engineering and Management in Industrial System, 2015
The goal of lean six sigma method is to solve the problems of waste, especially defect. The goal of failure mode and effect analysis (FMEA) method is to be able to identify potential failures in the production process of e.g.
Mario Sarisky Dwi Ellianto, Purnomo Budi Santoso, Achmad As'ad Sonief   +2 more
doaj   +1 more source

Independent Orbiter Assessment (IOA): Analysis of the remote manipulator system [PDF]

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. The IOA approach features a top-down analysis of the hardware to determine failure modes, criticality ...
Grasmeder, R. F., Montgomery, A. D., Tangorra, F.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analisis Penyebab Kegagalan Produk Dining Chair dengan Menggunakan Metode Failure Mode Effects And Criticality Analysis(FMECA) di PT.Ebako Nusantara [PDF]

, 2016
PT. Ebako Nusantara is a company that produce furniture. Where in its production it can not be separated from the defective product.Defect often occured in the Dining Chair production process.
Bakhtiar, A. (Arfan), Kumalasari, L. A. (Lingga), Pujotomo, D. (Darminto)   +2 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Risk Management in the Medical Records Department of Alavi Hospital of Tabriz, Iran, Using Failure Mode and Effects Analysis Technique

مدیریت اطلاعات سلامت, 2017
Introduction: Health information is one of the key pillars of effective management of health care services, and has been recognized as the main factor in the operation and integrity of health systems. As most health information is provided by the medical
Shahla Shahbazi, Adel Mazaheri, Maryam Kashef, Leila Ghaderi Nansa   +3 more
doaj  

Fuzzy Inference System Development for Turbogenerator Failure Diagnosis on Floating Production Offloading and Storage Platform

Energies
This paper introduces a novel approach for diagnosing failures within a turbogenerator mineral lube oil system, employing a fuzzy inference system (FIS) model. The study leverages real operational data collected from supervisory monitoring sensors across
Patricio F. Castro, George Rossany Soares de Lira, Pablo Bezerra Vilar, Edson G. da Costa, Fabricio B. S. Carvalho   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Clinical risk assessment in intensive care unit

International Journal of Preventive Medicine, 2013
Background: Clinical risk management focuses on improving the quality and safety of health care services by identifying the circumstances and opportunities that put patients at risk of harm and acting to prevent or control those risks.
Saeed Asefzadeh, Mohammad H Yarmohammadian, Ahmad Nikpey, Golrokh Atighechian   +3 more
doaj