Results 1 to 10 of about 140,106 (268)

A Modified Failure Mode and Effects Analysis for Linear Accelerator Quality Assurance

Advances in Radiation Oncology
Purpose: Failure mode and effects analysis (FMEA) is a proactive method for evaluating failure modes and the consequences of those failures. In radiation therapy, a risk-based approach such as this can be used to inform and drive the quality assurance ...
Nicole Jessop, DClinSci, Jamie Fairfoul, MSc   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Estimating the Theoretical and Empirical Probability Coefficients of Oil Pipeline Transport Infrastructure Failure Modes in Nigeria’s Coastal Ecosystem: Panacea for Non Optimal Deployment of Pipeline Safety and Security Management Systems

Logi, 2018
Failure of oil pipeline transport infrastructure in Nigeria’s coastal ecosystem has continued to pose serious environmental problems with consequent economic effects.
Nwokedi Theophilus Chinonyerem, Nnadi Kenneth U.   +1 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Numerical Investigation of Bedding Rock Slope Potential Failure Modes and Triggering Factors: A Case Study of a Bridge Anchorage Excavated Foundation Pit Slope

Applied Sciences
The analysis of slope failure modes is essential for understanding slope stability. This study investigated the failure modes and triggering factors of a rock slope using the limit equilibrium method, finite differences method, and exploratory factor ...
Songling Han, Changming Wang
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Ship-To-Ship Liquefied Natural Gas Bunkering Risk Assessment by Integrating Fuzzy Failure Mode and Effect Analysis and the Technique for Order Preference by Similarity to an Ideal Solution

Journal of Marine Science and Engineering
An increasing demand can be observed in ship-to-ship (STS) liquefied natural gas (LNG) bunkering operations, and the failures involved may lead to considerable casualties or environmental damage.
Wei Feng, Zichun Wang, Xirui Dai, Shengli Dong, Weiliang Qiao, Xiaoxue Ma   +5 more
doaj   +1 more source

Mathematical Modeling of Criteria Weighting and Risk Priority by Using Deviation Value Step-Wise in Energy Analysis for Double-Pipe Heat Exchangers [PDF]

Journal of Renewable Energy and Environment
Failure Mode and Effects Analysis (FMEA) is utilized for risk appraisal in various domains. In the FMEA methodology, each failure mode is evaluated by considering three risk factors: severity (S), occurrence (O), and detection (D). Subsequently, the Risk
Farhad Gholami, Iraj Mirzaee, Mortaza Khalilian   +2 more
doaj   +1 more source