Results 41 to 50 of about 962,464 (311)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Probabilistic Model-Based Safety Analysis

, 2010
Model-based safety analysis approaches aim at finding critical failure combinations by analysis of models of the whole system (i.e. software, hardware, failure modes and environment).
Alessandra Di Pierro, AVACS Funding Proposal, C. Baier, D. Bosnacki, David N. Jansen, Dr. W. Vesley, E. Clarke, Eckard Böde, F. Ortmeier, F. Ortmeier, Frank Ortmeier, Frank Ortmeier, Fran¸ cois Vernadat, Gethin Norman, Hans Hansson, Holger Hermanns, Holger Hermanns, Hr akan L. S. Younes, J.-P. Katoen, J.-P. Katoen, Jiri Barnat, Joost-Pieter Katoen, K. L. McMillan, L. Grunske, M. Bozzano, M. Bozzano, M. Bozzano, M. Güdemann, M. Kwiatkowska, M. Kwiatkowska, M. v Cepin, Marco Bozzano, Marco Bozzano, Martin Walker, Matthias Güdemann, Matthias Güdemann, MOD0058, N. Halbwachs, O. Akerlund, Parosh Aziz Abdulla, Peter B. Ladkin, Robin E. McDermott, RTCA, SAE-AS5506, SAE-AS5506/1, T. Peikenkamp   +45 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Reliability analysis of composite sandwich structure for fuselage skin based on surrogate model

Xibei Gongye Daxue Xuebao, 2022
Composite structures are characterized by multiple source uncertainties in mechanical properties, geometric dimension, etc., and multiple failure modes, which bring challenges to their design and application.
DING Zhendong, LI Hongshuang, GUAN Xiaole   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Failure mode analysis of the Endologix endograft [PDF]

Journal of Vascular Surgery, 2015
Type III (T-III) endoleaks following endovascular aneurysm repair (EVAR) remain a major concern. Our center experienced a recent concentration of T-III endoleaks requiring elective and emergency treatment and prompted our review of all EVAR implants over a 40-month period from April 2011 until August 2014.
Lemmon, Gary W., Motaganahalli, Rahgu L., Chang, Tiffany, Slaven, James, Aumiller, Ben, Kim, Bradford J., Dalsing, Michael C.   +6 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Reliability-Based Robust Design of Mechanical Components with Correlated Failure Modes Based on Moment Method

Advances in Mechanical Engineering, 2014
There are usually several potential failure modes in mechanical components. The conventional model for the system analysis is built under the condition that all failure modes are independent of each other.
Hao Lu, Yonghui He, Yimin Zhang
doaj   +1 more source