Results 61 to 70 of about 962,464 (311)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Estimating the Theoretical and Empirical Probability Coefficients of Oil Pipeline Transport Infrastructure Failure Modes in Nigeria’s Coastal Ecosystem: Panacea for Non Optimal Deployment of Pipeline Safety and Security Management Systems

Logi, 2018
Failure of oil pipeline transport infrastructure in Nigeria’s coastal ecosystem has continued to pose serious environmental problems with consequent economic effects.
Nwokedi Theophilus Chinonyerem, Nnadi Kenneth U.   +1 more
doaj   +1 more source

Automated Mixed Traffic Vehicle (AMTV) technology and safety study [PDF]

Technology and safety related to the implementation of an Automated Mixed Traffic Vehicle (AMTV) system are discussed. System concepts and technology status were reviewed and areas where further development is needed are identified.
Johnston, A. R., Peng, T. K. C., Vivian, H. C., Wang, P. K.   +3 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Numerical Investigation of Bedding Rock Slope Potential Failure Modes and Triggering Factors: A Case Study of a Bridge Anchorage Excavated Foundation Pit Slope

Applied Sciences
The analysis of slope failure modes is essential for understanding slope stability. This study investigated the failure modes and triggering factors of a rock slope using the limit equilibrium method, finite differences method, and exploratory factor ...
Songling Han, Changming Wang
doaj   +1 more source

Compression failure of angle-ply laminates [PDF]

The present work deals with modes and mechanisms of failure in compression of angle-ply laminates. Experimental results were obtained from 42 angle-ply IM7/8551-7a specimens with a lay-up of ((plus or minus theta)/(plus or minus theta)) sub 6s where ...
Hyer, Michael W., Peel, Larry D., Shuart, Mark J.   +2 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Ship-To-Ship Liquefied Natural Gas Bunkering Risk Assessment by Integrating Fuzzy Failure Mode and Effect Analysis and the Technique for Order Preference by Similarity to an Ideal Solution

Journal of Marine Science and Engineering
An increasing demand can be observed in ship-to-ship (STS) liquefied natural gas (LNG) bunkering operations, and the failures involved may lead to considerable casualties or environmental damage.
Wei Feng, Zichun Wang, Xirui Dai, Shengli Dong, Weiliang Qiao, Xiaoxue Ma   +5 more
doaj   +1 more source

Mathematical Modeling of Criteria Weighting and Risk Priority by Using Deviation Value Step-Wise in Energy Analysis for Double-Pipe Heat Exchangers [PDF]

Journal of Renewable Energy and Environment
Failure Mode and Effects Analysis (FMEA) is utilized for risk appraisal in various domains. In the FMEA methodology, each failure mode is evaluated by considering three risk factors: severity (S), occurrence (O), and detection (D). Subsequently, the Risk
Farhad Gholami, Iraj Mirzaee, Mortaza Khalilian   +2 more
doaj   +1 more source

Independent Orbiter Assessment (IOA): Analysis of the remote manipulator system [PDF]

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) are presented. The IOA approach features a top-down analysis of the hardware to determine failure modes, criticality ...
Grasmeder, R. F., Montgomery, A. D., Tangorra, F.   +2 more
core   +1 more source