Results 111 to 120 of about 954,912 (290)

A Novel Hybrid Methodology for Loss of Containment Accident Risk Assessment of Chemical Storage Tank Based on RPN Considering the Expert Epistemic Uncertainty

Chemical Engineering Transactions
In the petrochemical industry, storage tank failures may lead to unfavorable consequences or even catastrophic events. The risk management of chemical tank farms must identify all possible failure modes and reduce the risk for critical failure modes ...
Hongrui Jiang, Long Ding, Jie Ji, Jiping Zhu   +3 more
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Dual-Level Electric Submersible Pump (ESP) Failure Classification: A Novel Comprehensive Classification Bridging Failure Modes and Root Cause Analysis

Energies
Electric submersible pumps (ESPs) are critical for artificial lift operations; however, they are prone to frequent failures, often resulting in high operational costs and production downtime. Traditional ESP failure classifications are limited by lack of
Mostafa A. Sobhy, Gehad M. Hegazy, Ahmed H. El-Banbi   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Ply-level failure analysis of a graphite/epoxy laminate under bearing-bypass loading [PDF]

A combined experimental and analytical study was conducted to investigate and predict the failure modes of a graphite/epoxy laminate subjected to combined bearing and bypass loading.
Crews, J. H., Jr., Naik, R. A.
core   +1 more source

Interaction of crippling and torsional-flexural instabilities for centrally loaded columns [PDF]

, 1970
Empirical technique predicts failure loads for centrally loaded columns with thin-walled, open cross sections.
Walls, J. C.
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

On energy mechanism of rate-dependent failure mode evolution in plain weave composite

Polymer Testing
The intricate failure modes and the yet unclear rate dependency of carbon fiber reinforced plain weave composite materials pose a challenge to mechanics researchers.
Yongshuai Wang, Qiong Deng, Lianyang Chen, Haodong Wang, Tao Suo, Cunxian Wang   +5 more
doaj   +1 more source

Analysis, testing, and evaluation of faulted and unfaulted Wye, Delta, and open Delta connected electromechanical actuators [PDF]

Mathematical models capable of simulating the transient, steady state, and faulted performance characteristics of various brushless dc machine-PSA (power switching assembly) configurations were developed.
Demerdash, N. A., Nehl, T. W.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source