Results 31 to 40 of about 442,844 (266)
New Mathematical Model to Analyze Security of Sharding-Based Blockchain Protocols
IEEE Access, 2019 In recent years, the scalability issue of blockchain protocols has received huge attention. Sharding is one of the most promising solutions to scale blockchain.
Abdelatif Hafid +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Structural Reliability Algorithms of Kriging Model Based on Improved Learning Strategy
Xibei Gongye Daxue Xuebao, 2020 Aiming at the problems of implicit and highly nonlinear limit state function in the process of reliability analysis of mechanical products, a reliability analysis method of mechanical structures based on Kriging model and improved EGO active learning ...
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Tongxin xuebao, 2019 In order to gain insight into the relationship between the failure probability and the spectrum efficiency,both failure probability (FP) and load balancing (LB) were attempted to minimize in flexible bandwidth optical networks.An optimized FP-LB ...
Bowen CHEN, Xiaodong FU, Yu LEI
doaj +2 more sources
Probability of fatigue failure in brick masonry under compressive loading [PDF]
, 2018 © 2018 Elsevier Ltd Long-term fatigue tests under compressive loading were performed on low-strength brick masonry prisms under laboratory conditions. The number of loading cycles to failure were recorded and used to investigate the suitability of the ...
Tomor, AK +8 more
core +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Energies, 2018 Mechanical damage is a major factor limiting the long-term stability of solid oxide fuel cells (SOFCs). Here, the mechanical stability of planar SOFCs consisting of Ni-YSZ anode/YSZ electrolyte/LSM-YSZ cathode (Ni=Nickel, YSZ=yttria-stabilized zirconia ...
Xiurong Fang, Jiang Zhu, Zijing Lin
doaj +1 more source
Predicting the probability of failure of timber bridges using fault tree analysis
, 2019 The resilience of a community in an extreme event depends mainly on the robustness of the critical infrastructures. Road bridges are a critical link of the road network, which plays a focal role in Australia’s economy, prosperity, social well-being and ...
Lokuge, Weena +3 more
core +1 more source