Results 51 to 60 of about 3,310,609 (261)

Effect of uncertainties in prediction models of shallow and deep foundations

Engineering and Applied Science Research, 2023
The primary objective in foundation design is to ensure that the foundation exhibits satisfactory behavior under regulatory loading conditions while addressing critical safety concerns. This study aims to investigate the impact of parameter uncertainties
Houcine Djeffal, Laid Rouaski, Smain Belkacemi   +2 more
doaj  

A Concise Transformation Combined With Adaptive Kriging Model for Efficiently Estimating Regional Sensitivity on Failure Probability

IEEE Access, 2019
Regional sensitivity on failure probability (RS-FP) can quantify the effect of the input region of interest (IRoI) on the failure probability and provide useful information for reliability based design optimization.
Jingyu Lei, Zhenzhou Lu, Yingshi Hu, Beixi Jia   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Analysis of sensitivity to operations’ failure probability.

, 2016
Analysis of sensitivity to operations’ failure probability.
Muhammad Imran Babar (708822), Mohd Adham Isa (3138336), Dayang N. A. Jawawi (708824), Awad Ali (3138339)   +3 more
core   +1 more source

An Innovative Linear Wireless Sensor Network Reliability Evaluation Algorithm

Sensors
In recent years, wireless sensor networks (WSNs) have become a crucial technology for infrastructure monitoring. To ensure the reliability of monitoring services, evaluating the network’s reliability is particularly important.
Tao Ma, Huidong Guo, Xin Li
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A probabilistic fatigue assessment diagram to get a guaranteed lifetime with a low probability of failure

, 2017
In order to guarantee a fatigue lifetime with a conventional and low probability of failure, a probabilistic fatigue assessment diagram is proposed as a tool.
Jallouf S., Casavola C., Pluvinage G., Pappalettere C.   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Estimating probability of fatigue failure of steel structures [PDF]

, 2020
The article deals with the analysis of failure probability of the effect of random factors in uencing fatigue crack propagation in a steel element under bending moment.
Kala, Z.
core   +1 more source

Multiple Factors Coupling Probability Calculation Model of Transmission Line Ice-Shedding

Energies
After a transmission line is covered by ice in winter, ice-shedding and vibration occurs under special meteorological and external dynamic conditions, which leads to intense transmission line shaking.
Hao Pan, Fangrong Zhou, Yi Ma, Yutang Ma, Ping Qiu, Jun Guo   +5 more
doaj   +1 more source