Results 61 to 70 of about 442,844 (266)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Overall Kaplan Meier failure probability curve.

open access: yes, 2022
Overall Kaplan Meier failure probability curve.
Diriba Ayala (10711955)   +14 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

The Market's View on the Probability of Banking Sector Failure: Cross-Country Comparisons [PDF]

open access: yes
Considering the increasingly international banks of today, the health of a country's banking sector is crucial not only to the country's growth and prosperity but also to the rest of the international financial community.
Hans Byström
core  

Reliability analysis of mechanical components containing random flaws [PDF]

open access: yes, 2006
The goal of structural reliability is to assure that a structure adequately performs its intended function when operating under specified environmental conditions.
Giuseppe Iacopino, Iacopino, G.
core  

A probabilistic fatigue assessment diagram to get a guaranteed lifetime with a low probability of failure

open access: yes, 2017
In order to guarantee a fatigue lifetime with a conventional and low probability of failure, a probabilistic fatigue assessment diagram is proposed as a tool.
Jallouf S.   +3 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Time Estimation and Resource Minimization Scheme for Apache Spark and Hadoop Big Data Systems With Failures

open access: yesIEEE Access, 2019
Apache Spark and Hadoop are open source frameworks for big data processing, which have been adopted by many companies. In order to implement a reliable big data system that can satisfy processing target completion times, accurate resource provisioning ...
Jinbae Lee, Bobae Kim, Jong-Moon Chung
doaj   +1 more source

Seismic fragility analysis of two-story and three-span metro station structures based on IDA method

open access: yesYantu gongcheng xuebao, 2020
Based on the non-linear soil-structure interaction model for a two-storey and three-span metro station in a typical underground engineering site, an IDA (incremental dynamic analysis)-based structural seismic fragility analysis method is introduced for ...
ZHONG Zi-lan , SHEN Yi-yao , HAO Ya-ru , LI Li-yun , DU Xiu-li 1
doaj   +1 more source

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