Results 61 to 70 of about 2,648,329 (307)

A Concise Transformation Combined With Adaptive Kriging Model for Efficiently Estimating Regional Sensitivity on Failure Probability

open access: yesIEEE Access, 2019
Regional sensitivity on failure probability (RS-FP) can quantify the effect of the input region of interest (IRoI) on the failure probability and provide useful information for reliability based design optimization.
Jingyu Lei   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

An Innovative Linear Wireless Sensor Network Reliability Evaluation Algorithm

open access: yesSensors
In recent years, wireless sensor networks (WSNs) have become a crucial technology for infrastructure monitoring. To ensure the reliability of monitoring services, evaluating the network’s reliability is particularly important.
Tao Ma, Huidong Guo, Xin Li
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Weibull Failure Probability Estimation Based on Zero-Failure Data [PDF]

open access: yesMathematical Problems in Engineering, 2015
Reliability testing is often carried out with small sample sizes and short duration because of increasing costs and the restriction of development time. Therefore, for highly reliable products, zero-failure data are often collected in such tests, which could not be used to evaluate reliability by traditional methods.
Jiang, Ping   +3 more
openaire   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Multiple Factors Coupling Probability Calculation Model of Transmission Line Ice-Shedding

open access: yesEnergies
After a transmission line is covered by ice in winter, ice-shedding and vibration occurs under special meteorological and external dynamic conditions, which leads to intense transmission line shaking.
Hao Pan   +5 more
doaj   +1 more source

Reliability analysis of pipeline in fault area based on BP-MC method

open access: yesYou-qi chuyun, 2020
Strike-slip fault is a common geologic hazard for buried pipelines. The fault-induced ground displacement often leads to excessive deformation and failure of pipelines, so it is of great significance to carry out reliability analysis of pipelines in ...
Qian ZHENG, Hong ZHANG, Xiaoben LIU
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Reliability Assessment of Tapered Stress Joint under Inclined Wellhead of TLP

open access: yesShiyou jixie, 2019
To study the influence of random variables on the reliability of tapered stress joint strength, a reliability calculation method based on Kriging model is proposed.
Wang Kang   +5 more
doaj  

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