Results 61 to 70 of about 3,310,609 (261)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Reliability Assessment of Tapered Stress Joint under Inclined Wellhead of TLP

open access: yesShiyou jixie, 2019
To study the influence of random variables on the reliability of tapered stress joint strength, a reliability calculation method based on Kriging model is proposed.
Wang Kang   +5 more
doaj  

Reliability analysis of pipeline in fault area based on BP-MC method

open access: yesYou-qi chuyun, 2020
Strike-slip fault is a common geologic hazard for buried pipelines. The fault-induced ground displacement often leads to excessive deformation and failure of pipelines, so it is of great significance to carry out reliability analysis of pipelines in ...
Qian ZHENG, Hong ZHANG, Xiaoben LIU
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Development status and countermeasures of quantitative risk assessment technology for oil & gas pipeline

open access: yesYou-qi chuyun, 2020
Pipeline risk assessment is the key process of pipeline integrity management. With the continuous improvementof refinement requirements for pipeline integrity management, pipeline risk assessment also transfers from semi-quantitativeassessment to ...
Xin WANG   +7 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Properties of distributions with increasing failure rate [PDF]

open access: yes
This paper solves the search for interior solutions to optimization problems using stochastic variables. This is done by way of some new properties of distribution functions with increasing failure rates as characterized in Barlow and Proschan (1965 ...
Brusset, Xavier
core  

Reliability analysis of bedrock laminar slope stability considering variability of saturated hydraulic conductivity of soil under heavy rainfall

open access: yesYantu gongcheng xuebao, 2017
The saturated permeability coefficient of soil is an inherent variable due to its inhomogeneity and the inaccuracy of monitoring. To explore the stability and failure probability of bedrock laminar slope under heavy rainfall, a reliability analysis model
QIN Xiao-hua 1,2, LIU Dong-sheng 3, SONG Qiang-hui 1,2, WU Yue 3, ZHANG Yu 1,2, YE Yong 4
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Approximating sensitivity of failure probability in reliability-based design optimization

open access: yes, 2015
This paper presents an efficient numerical method for approximating the parameter sensitivity of the failure probability with respect to design parameters.
Paulino, Glaucio H.   +2 more
core   +1 more source

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