Results 81 to 90 of about 2,648,329 (307)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Reliability analysis of bedrock laminar slope stability considering variability of saturated hydraulic conductivity of soil under heavy rainfall

open access: yesYantu gongcheng xuebao, 2017
The saturated permeability coefficient of soil is an inherent variable due to its inhomogeneity and the inaccuracy of monitoring. To explore the stability and failure probability of bedrock laminar slope under heavy rainfall, a reliability analysis model
QIN Xiao-hua 1,2, LIU Dong-sheng 3, SONG Qiang-hui 1,2, WU Yue 3, ZHANG Yu 1,2, YE Yong 4
doaj   +1 more source

Reliability approach for safe designing on a locking system [PDF]

open access: yes, 2010
The aim of this work is to predict the failure probability of a locking system. This failure probability is assessed using complementary methods: the First-Order Reliability Method (FORM) and Second-Order Reliability Method (SORM) as approximated methods,
ARNOUX, Philippe   +3 more
core   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Flexural fatigue strength and failure probability of concrete beam containing nano-silica and steel fibers [PDF]

open access: yesNumerical Methods in Civil Engineering
Roller-compacted concrete (RCC) shares components with conventional concrete but differs in aggregate size, workability, mix design, and construction methods.
Yaghoub Mohammadi, Hassan Rezaei Dolagh
doaj   +1 more source

Does Information Transparency Decrease Coordination Failure? [PDF]

open access: yes
This study experimentally tests the effect of information transparency on the probability of coordination failure in global games with finite signals.
Regina M. Anctil   +3 more
core  

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

On mixture failure rate ordering [PDF]

open access: yes
Mixtures of increasing failure rate distributions (IFR) can decrease at least in some intervals of time. Usually this property can be observed asymptotically as time tends to infinity.
Maxim S. Finkelstein, Veronica Esaulova
core  

Heterotropic regulation and negative homotropic cooperativity

open access: yesFEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea   +5 more
wiley   +1 more source

Asymptotic behavior of mixture failure rates [PDF]

open access: yes
Mixtures of increasing failure rate distributions (IFR) can decrease at least in some intervals of time. Usually this property is observed asymptotically as time tends to infinity , which is due to the fact that a mixture failure rate is ‘bent down’, as ...
Maxim S. Finkelstein, Veronica Esaulova
core  

Home - About - Disclaimer - Privacy