Results 91 to 100 of about 2,827,460 (258)

Properties of distributions with increasing failure rate [PDF]

This paper solves the search for interior solutions to optimization problems using stochastic variables. This is done by way of some new properties of distribution functions with increasing failure rates as characterized in Barlow and Proschan (1965 ...
Brusset, Xavier
core   +1 more source

Exact Failure Frequency Calculations for Extended Systems [PDF]

arXiv, 2006
This paper shows how the steady-state availability and failure frequency can be calculated in a single pass for very large systems, when the availability is expressed as a product of matrices. We apply the general procedure to $k$-out-of-$n$:G and linear consecutive $k$-out-of-$n$:F systems, and to a simple ladder network in which each edge and node ...
arxiv  

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Choice of mode of operations of the thermoelectrical cooling device, ensuring the minimal failure rate [PDF]

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2008
A comparative analysis of TCD reliability has been carried out for different current modes. The paper presents relations allowing to determine the relative value of the operating current at a predetermined temperature difference, which provides the ...
Zaikov V. P., Kinshova L. A., Moiseev V. F., Efremov V. I., Melnik Yu. V.   +4 more
doaj  

Asymptotic efficiency of restart and checkpointing [PDF]

arXiv, 2018
Many tasks are subject to failure before completion. Two of the most common failure recovery strategies are restart and checkpointing. Under restart, once a failure occurs, it is restarted from the beginning. Under checkpointing, the task is resumed from the preceding checkpoint after the failure.
arxiv  

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

Molecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen, Pieter‐Jan Volders, Ellen Geerdens, Severine Berden, Joni Van der Meulen, Aaron De Cock, Stefanie Vermeire, Jacques Van Huysse, Marie de Barsy, Gabriela Beniuga, Wendy W. J. de Leng, Anne M. L. Jansen, Imke Demers, Zeliha Ozgur, Hendrikus Jan Dubbink, Ernst‐Jan M. Speel, Wilfred F. J. van IJcken, Brigitte Maes   +17 more
wiley   +1 more source

Foreseeing the reliability indexes of two-cascade thermo-electric cooling device in the mode of ΔTmax [PDF]

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2009
There has been offered a correlation model of reliability indexes for two-cascade TED of set design with basic meaningful parameters at successive electric connection of cascades.
Zaykov V. P., Kinshova L. A., Moiseev V. Ph., Kazanghi L. D., Klyuchnikov D. A.   +4 more
doaj  

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Fracture size effects in nanoscale materials: the case of graphene

, 2015
Nanoscale materials display enhanced strength and toughness but also larger fluctuations and more pronounced size effects with respect to their macroscopic counterparts.
Sellerio, Alessandro Luigi, Taloni, Alessandro, Zapperi, Stefano   +2 more
core   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source