Results 91 to 100 of about 45,359 (268)

The discrete Gompertz–Makeham distribution for multidisciplinary data analysis

AIMS Mathematics
The Gompertz–Makeham (GM) distribution has the flexibility to model real-world lifetime data with increasing, decreasing, or constant hazard rates, making it exceptionally valuable for applications in survival analysis, actuarial science, demography, and
Ahmed Elshahhat, Hoda Rezk, Refah Alotaibi   +2 more
doaj   +1 more source

Influence of the effectiveness of raw materials on the reliability of thermoelectric cooling devices. Part I: single-stage TEDs

Tekhnologiya i Konstruirovanie v Elektronnoi Apparature, 2015
Increase of the reliability of information systems depends on the reliability improvement of their component elements, including cooling devices, providing efficiency of thermally loaded components. Thermoelectric devices based on the Peltier effect have
V. P. Zaikov, V. I. Meshcheryakov, A. A. Gnatovskaya, Yu. I. Zhuravlev   +3 more
doaj   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Maximum Likelihood Estimation for Distributions with Monotone Failure Rate [PDF]

, 1965
Albert W. Marshall, Frank Proschan
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Computer-modified paramedian approach technique reduces failures and alleviates pain in lumbar puncture: a prospective comparative study

Frontiers in Medicine
BackgroundThe conventional midline approach for lumbar puncture (MAT-LP) has a relatively low success rate of 70%. The paramedian approach can increase the effective puncture area and success rate but lacks standardized guidelines. This study evaluated a
Yuan-Dong Zhuang, Hai-Shu Xie, Jing Chen, Guo-Hua Wu, Jian-Feng Wu, Jian-Feng Wu, Chun-Mei Chen, Chun-Mei Chen   +7 more
doaj   +1 more source

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

TESTS FOR MONOTONE FAILURE RATE BASED ON NORMALIZED SPACINGS [PDF]

, 1967
Peter J. Bickel, Kjell A. Doksum
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

ASYMPTOTICALLY OPTIMAL STATISTICS IN SOME MODELS WITH INCREASING FAILURE RATE AVERAGES [PDF]

, 1966
Kjell A. Doksum
openalex   +1 more source