Results 91 to 100 of about 4,219,187 (348)
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
The new generalized inverse Weibull distribution
پژوهشهای ریاضی, 2015 Failure rate is one of the important concepts in reliability theory. In this paper, we introduce a new distribution function containing four parameters based on inverse Weibull distribution.
A Dostmoradi, M Zadkarami, V Bahrami
doaj
Some Properties of Gamma Generated Distributions
Statistica, 2015 Based on standard probability distributions, new families of univariate distributions have been introduced and their properties studied by many authors.
Manisha Pal, Montip Tiensuwan
doaj +1 more source
Exchange-rate volatility, exchange-rate disconnect, and the failure of volatility conservation [PDF]
Empirical analysis of exchange rates has produced puzzles that conventional models of exchange rates cannot explain. Here we deal with four puzzles regarding both real and nominal exchange rates, which are robust and inconsistent with standard theory ...
Alexei Deviatov, Igor Dodonov
core
Prediction of gas leakage of environmental control systems [PDF]
, 1970 Mathematical models of leakage configurations and various flow theories are presented with the substantive experimental test data to provide background material for future design and failure analysis.
Jackson, J. K., Thomas, E. C.
core +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
IEEE Access, 2019 The main purpose of this paper is to design a scientific-based probabilistic model based on Markov chains, to calculate reliability indicators, such as mean time between failure (MTBF) and mean time to failure (MTTF) based on probabilities, to compute ...
Simona-Vasilica Oprea +3 more
doaj +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Yuanzineng kexue jishuAs the core of high-voltage direct-current transmission technology, the DC converter valve and its key power device thyristor face a high risk of failure caused by atmospheric neutron when operating in high-altitude areas. The atmospheric neutron failure
PENG Chao1, ZHOU Yang2, CHEN Zhongyuan2, LEI Zhifeng1, MA Teng1, ZHANG Zhangang1, ZHANG Hong1, HE Yujuan1
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