Results 71 to 80 of about 4,219,187 (348)
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Aggregate economy risk and company failure: An examination of UK quoted firms in the early 1990s [PDF]
, 2003 Considerable attention has been directed in the recent finance and economics literature to issues concerning the effects on company failure risk of changes in the macroeconomic environment.
Hunter, J, Isachenkova, N
core
Rate dependent shear bands in a shear transformation zone model of amorphous solids [PDF]
, 2008 We use Shear Transformation Zone (STZ) theory to develop a deformation map for amorphous solids as a function of the imposed shear rate and initial material preparation.
D. Griggs +5 more
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
IEEE Access, 2019 The offshore wind farms (OWF) are susceptible to the severe weather, which can cause the increase of component failure rate and has significant influence on the maintenance process and the reliability of wind farms.
Huawei Chao +5 more
doaj +1 more source
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Iranian Journal of Electrical and Electronic Engineering, 2019 In this paper, a new method for modelling and estimation of reliability parameters of power transformer components in distribution and transmission voltage levels for preventive-corrective maintenance schedule of transformers is proposed. In this method,
H. Sh. Solari, B. Majidi, M. Moazzami
doaj
Performance and Reliability of Wind Turbines: A Review
Energies, 2017 Performance (availability and yield) and reliability of wind turbines can make the difference between success and failure of wind farm projects and these factors are vital to decrease the cost of energy. During the last years, several initiatives started
Sebastian Pfaffel +2 more
doaj +1 more source