Results 81 to 90 of about 1,548,929 (297)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

A Design of Workflow-Based Automated Failure Recovery Framework in IoT Edge Environment

open access: yesIEEE Access
In IoT Edge environments, microservice-based architectures decompose workloads into functional units for efficient deployment and scaling across edge nodes.
Phuong Bac Ta   +2 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

vFFR: A Very Fast Failure Recovery Strategy Implemented in Devices With Programmable Data Plane

open access: yesIEEE Open Journal of the Communications Society
The rapid emergence of new applications and services, and their increased demand for Quality of Service (QoS), have a significant impact on the development of today’s communication networks.
David Franco   +4 more
doaj   +1 more source

COMPREHENSIVE DISASTER MANAGEMENT AND DEVELOPMENT: THE ROLE OF GEOINFORMATICS AND GEO-COLLABORATION IN LINKING MITIGATION AND DISASTER RECOVERY IN THE EASTERN CARIBBEAN [PDF]

open access: yes, 2008
The recurring failure of communities at risk to build mitigation into disaster recovery activities to reduce risks against future disaster events remains unresolved.
Huggins, Leonard James
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

A case series of cardiac amyloidosis patients supported by continuous‐flow left ventricular assist device

open access: yesESC Heart Failure, 2021
Varinder K. Randhawa   +10 more
doaj   +1 more source

Real‐time text tracking in natural scenes

open access: yesIET Computer Vision, 2014
The authors present a system that automatically detects, recognises and tracks text in natural scenes in real‐time. The focus of the author's method is on large text found in outdoor environments, such as shop signs, street names, billboards and so on ...
Carlos Merino‐Gracia, Majid Mirmehdi
doaj   +1 more source

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