Results 31 to 40 of about 2,543,940 (249)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

The principle of fairness of punishment

Visnik Nacional’nogo universitetu «Lvivska politehnika». Seria: Uridicni nauki, 2022
Принципи призначення покарання є окремою категорією кримінального права. Думки науковців щодо визначення поняття принципів призначення покарання та їх видів розходяться. Конкретний вичерпний перелік видів таких принципів сформулювати неможливо. Їх може бути безліч.
openaire   +3 more sources

FAIR Principles and Zenodo

, 2023
Presentation about FAIR principles and Zenodo.
Kirwan, Luke, Hackstock, Philip
openaire   +4 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Measuring the FAIR Principles

, 2019
A brief description of some past work related to FAIRness of metadata and data. This presentation was given in July 2019 at the Earth Science Information Partners (ESIP) Summer Meeting held in Tacoma, Washington.
Habermann, Ted, Jones, Matthew, O'Brien, Margaret, Slaughter, Peter   +3 more
openaire   +1 more source

Putting FAIR Principles in the Context of Research Information: FAIRness for CRIS and CRIS for FAIRness

Proceedings of the 14th International Joint Conference on Knowledge Discovery, Knowledge Engineering and Knowledge Management, 2022
Full-text conference paper offered under a CC BY-NC-ND 4.0 ...
Otmane Azeroual, Joachim Schöpfel, Janne Pölönen, Anastasija Nikiforova   +3 more
openaire   +4 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

FAIR Data Principles

, 2022
This slide deck contains presentation of following topics: 1. Overview of FAIR data principles 2. Controlled vocabularies 3. DCAT schema 4. Share Wind Semantic Data Portal (Kristina Tomicic)
openaire   +2 more sources