Results 51 to 60 of about 110,412 (287)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

FAIR Principles: Baseline Comments.

open access: yes, 2020
In the early stages of the FAIRsFAIR Project it became clear that the same comments and questions related to the FAIR Principles were being raised by many of those undertaking related work.
Jessica Parland-von Essen   +8 more
core   +1 more source

Overview about the FAIR principles

open access: yes, 2022
This presentation is a short overview of FAIR principles covering the following: What does FAIR mean? FAIR elements Open is not FAIR, FAIR is not Open It was given at the EOSC-Pillar T6.2 workshop on may 13th ...
Lazzeri, Emma
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Pacific Coast Committee on American Principles and Fair Play

open access: yes, 1942
Fundraising and membership letter from the Pacific Coast Committee on American Principles and Fair Play.Personal correspondence, organizational records, government documents, publications, and other papers created or collected by Joseph R.
Pacific Coast Committee on American Principles and Fair Play: author
core   +1 more source

FAIR Data Principles

open access: yes, 2022
This slide deck contains presentation of following topics: 1. Overview of FAIR data principles 2. Controlled vocabularies 3. DCAT schema 4. Share Wind Semantic Data Portal (Kristina Tomicic)
openaire   +2 more sources

Putting FAIR Principles in the Context of Research Information: FAIRness for CRIS and CRIS for FAIRness

open access: yesProceedings of the 14th International Joint Conference on Knowledge Discovery, Knowledge Engineering and Knowledge Management, 2022
Full-text conference paper offered under a CC BY-NC-ND 4.0 ...
Otmane Azeroual   +3 more
openaire   +4 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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