Results 81 to 90 of about 965,717 (357)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Foster v. Chatman: Clarifying the Batson Test for Discriminatory Peremptory Strikes [PDF]

open access: yes, 2016
Historically, peremptory challenges were thought necessary to ensure fair and impartial juries, but the tactic has also been widely used by prosecutors for racially discriminatory purposes.
Daly, Meghan
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Human trafficking, victims’ rights and fair trials [PDF]

open access: yes, 2018
Cases of human trafficking are known to be difficult to prosecute. In this article we identify several issues in the law of evidence that may contribute to these difficulties.
Fouladvand, Shahrzad, Ward, Tony
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

The Right to Cross-Examination and Witness Protection in Ethiopia: Comparative Overview

open access: yesMizan Law Review, 2018
Cross-examination particularly in the context of criminal trial is a human right recognized in international human rights law and the Ethiopian constitution.
Tadesse Melaku
doaj   +1 more source

Indigenous justice and the right to a fair trial [PDF]

open access: yes, 2017
Corradi ’ s analysis of how the right to a fair trial may be interpreted cross-culturally suggests that areas of tension between indigenous procedural norms and mainstream interpretations of this right may open windows of opportunity for exchange and ...
Corradi, Giselle
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

La decisione giusta

open access: yesRevista Ítalo-Española de Derecho Procesal, 2019
Nonostante le varie controversie che circondano il concetto di “giustizia”, quando si parla di una “decisione giusta”, il concetto può essere ridotto a schemi razionali e abbastanza controllabili sul suo significato.
Michele Taruffo
doaj  

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