Results 131 to 140 of about 18,679 (292)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
THE CREATIVE ACCOUNTING CONCEPT IN THE CURRENT ECONOMIC CONTEXT APPROACHED FROM DIFFERENT PERSPECTIVES IN THE LIGHT OF MOTIVATIONS UNDERLYING THE MODELLING OF FISCAL YEAR RESULT [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2015 This article is trying to tackle the relationships which exist between three dimensions of economic reality. The objective of this article is to contribute to the study of determinants of accounting result management.
GÎNŢA ANCA IOANA
doaj
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
What is representation within PWP training [PDF]
Research shows that clients from racially minoritised communities have lower access rates to primary care mental health services (Baker, 2020), for reasons such as stigma (Eylem et al., 2020), lack of understanding (Memon, 2016) and mistrust of mental ...
Kunorubwe, Taf, Odusote, Faithful
core
The Perception of Discretionary Accounting Regulations on Asset Write-offs
Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2019 Flexibility of accounting norms (in the scope of asset write-offs) was introduced in order to enable entities to apply solutions adjusted to their specific character, creating+-* the possibility to use discrete decision-making in a way that undermines ...
Ewa Wanda Maruszewska
doaj
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Gadamer’s Play as a Criterion for Musical Representation
Critical HermeneuticsThis article explores Gadamer's notion of play as a hermeneutic criterion for understanding subjectivity in musical practice. Based on a distinction between three modes of representation of the work – faithful performance, version, and interpretation ...
Mario Blanco-Tascón
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
The interrelation among faithful representation (reliability), corruption and IFRS adoption: An empirical investigation [PDF]
, 2015 Purpose - The degree of corruption, among other things, indicates the nonimplementation of laws, weak enforcement of legal sanctions and the existence of nontransparent economic transactions.
Kythreotis, Alexios
core
Methods and ProtocolsThe past several decades have borne witness to several breakthroughs and paradigm shifts within the field of cardiovascular medicine, but one component that has remained constant throughout this time is the need for accurate animal models for the ...
Christopher R. Stone +8 more
doaj +1 more source