Results 121 to 130 of about 3,110,326 (313)

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Designing the user experience of architecture with virtual reality [PDF]

open access: yes, 2022
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo termsThe student, Faithful Oladeji, accepted the attached license on 2022-07-15 at 16:02.The student, Faithful ...
Oladeji, Faithful
core  

What is representation within PWP training

open access: yes
Research shows that clients from racially minoritised communities have lower access rates to primary care mental health services (Baker, 2020), for reasons such as stigma (Eylem et al., 2020), lack of understanding (Memon, 2016) and mistrust of mental ...
Kunorubwe, Taf, Odusote, Faithful
core   +6 more sources

Au fil de Sirona… la déesse de Mediolanum/Mâlain

open access: yesArchéopages, 2016
In 2014, the realization of a diagnosis in Mâlain (Côte-d'Or) offered the opportunity to better discern the site of the western sanctuary of Mediolanum, ancient antique agglomeration of the city of Lingons.
Marie-Agnès Widehen, Michel Kasprzyk
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Groups with faithful blocks

open access: yes, 1975
A necessary and sufficient condition is given for a finite group to have a p p -block with kernel 1. This extends a theorem of Gaschütz on the existence of a faithful irreducible representation of a finite group.
H. Pahlings
core   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

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