Results 101 to 110 of about 3,110,326 (313)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Individual representation: A different approach to political representation [PDF]

, 2012
This article presents a new conceptualisation and measure of political representation to complement conventional approaches. Individual representation scores place the individual rather than the legislature at the centre, providing a fresh perspective on
Ruedin, Didier
core   +1 more source

The Relationship between Zhedanov's Algebra AW(3) and the Double Affine Hecke Algebra in the Rank One Case

Symmetry, Integrability and Geometry: Methods and Applications, 2007
Zhedanov's algebra AW(3) is considered with explicit structure constants such that, in the basic representation, the first generator becomes the second order q-difference operator for the Askey-Wilson polynomials. It is proved that this representation is
Tom H. Koornwinder
doaj  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Bounds on multiplicities of symmetric pairs of finite groups

Forum of Mathematics, Sigma
Let $\Gamma $ be a finite group, let $\theta $ be an involution of $\Gamma $ and let $\rho $ be an irreducible complex representation of $\Gamma $ .
Avraham Aizenbud, Nir Avni
doaj   +1 more source

Constructing faithful matrix representations of Lie algebras

Proceedings of the 1997 international symposium on Symbolic and algebraic computation - ISSAC '97, 1997
By Ados theorem every nite dimensional Lie algebra over a eld of characteristic zero has a faithful nite dimensional representation We consider the algorithmic problem of constructing such a representation for Lie algebras given by a multiplication table An eective version of Ados theorem is proved.
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

THE LEFT REGULAR REPRESENTATION OF A COMMUTATIVE SEPARATIVE SEMIGROUP [PDF]

Journal of Sciences, Islamic Republic of Iran, 1992
In this paper, a commutative semigroup will be written as a disjoint union of its cancellative subsemigroups. Based on this fact we will define the left regular representation of a commutative separative semigroup and show that this representation is ...
doaj