Results 81 to 90 of about 252,651 (269)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Bounds on multiplicities of symmetric pairs of finite groups

Forum of Mathematics, Sigma
Let $\Gamma $ be a finite group, let $\theta $ be an involution of $\Gamma $ and let $\rho $ be an irreducible complex representation of $\Gamma $ .
Avraham Aizenbud, Nir Avni
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

THE LEFT REGULAR REPRESENTATION OF A COMMUTATIVE SEPARATIVE SEMIGROUP [PDF]

Journal of Sciences, Islamic Republic of Iran, 1992
In this paper, a commutative semigroup will be written as a disjoint union of its cancellative subsemigroups. Based on this fact we will define the left regular representation of a commutative separative semigroup and show that this representation is ...
doaj  

On AdS4 superspace and supergravity

Journal of High Energy Physics
In the N = 1 superspace, AdS4 supersymmetry is realized as the non-linear super coordinate transformations. The fermionic coordinates form a faithful non-linear representation of supersymmetry on their own.
Chen-Xu Han, Zhao-Long Wang, Yi Yan
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

{The faithful triangular representations of Kaloujnine $p$-groups over a $p$-element field

Karpatsʹkì Matematičnì Publìkacìï, 2011
The faithful triangular representations of finite Kaloujnine$p$-groups is studied. Images of generators of those groups aredescribed. Infinite-dimensional representation of the direct limitof Kaloujnine $p$-groups is regarded.
Y. G. Leonov
doaj  

Financial Information Quality Between Numerical Accuracy and Comprehensibility: Effects on Investment Decisions in the Context of the Bucharest Stock Exchange

International Journal of Financial Studies
The informational efficiency of stock prices is conditioned by the level of quality of financial reports, contributing to an accurate assessment of the company’s future performance. By approaching informational quality from two perspectives, we conducted
Daniela Mogîldea, Mihai Carp
doaj   +1 more source