Results 71 to 80 of about 18,679 (292)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Graph-algebras—faithful representations and mediating objects in mathematics [PDF]
, 2018 I consider the role of diagrams in contemporary mathematics. More specifically the role of certain diagrams—so-called directed graphs—will be investigated. I propose that these graphs act as mediating objects.
Carter, Jessica
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
A faithful polynomial representation of Out F3 [PDF]
, 1989 Let Fn be a free group of rank n and let Out Fn be its outer automorphism group. The main result of this paper is that Out F3 has a faithful representation as a group of automorphisms of the polynomial ring in seven variables over the integers.
James McCool
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Faithful permutation representations of toroidal regular maps [PDF]
, 2019 In this paper we list all possible degrees of a faithful transitive permutation representation of the group of symmetries of a regular map of types $\{4,4\}$ and $\{3,6\}$ and we give examples of graphs, called CPR-graphs, representing some of these ...
Piedade, Cláudio Alexandre +1 more
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Faithful π-nets. A graphical representation of the asynchronous π-calculus [PDF]
, 1998 Starting from the π-nets defined by Milner, we present a graphical formalism called faithful π-nets. The aim of these nets is to provide a graphical form to the systems with dynamically changing configurations. The faithful π-nets correspond precisely to
Rotaru, Mihai, Ciobanu, Gabriel
core +1 more source