Results 211 to 220 of about 219,223 (326)

AI‐Based Prediction of PROTAC‐ and Molecular Glue‐Mediated Ternary Complexes: A Comparative Evaluation of AlphaFold 3 and Boltz‐2

Archiv der Pharmazie, Volume 359, Issue 3, March 2026.
Superposition of the lowest RMSD predictions for the ternary complex of SMARCA2‐VHL. The AlphaFold 3 prediction is shown in cyan, the Boltz‐2 prediction in pink, and the reference X‐ray structure in green. ABSTRACT Proteolysis targeting chimeras (PROTACs) and molecular glues induce ligand‐mediated ternary complexes between an E3 ubiquitin ligase and a ...
Lino Riepenhausen, Anne‐Christin Sarnow, Dina Robaa, Wolfgang Sippl   +3 more
wiley   +1 more source

DMP1-Mediated FAK Activation Contributes to P Utilization of Broiler Osteoblasts by Suppressing FGF23 Expression. [PDF]

Biology (Basel)
Li T, Feng X, Zhang W, Zhao J, Zhang L, Hu Y, Cui X, Wang S, Luo X.   +8 more
europepmc   +1 more source

FAK Is Required for TGFβ-induced JNK Phosphorylation in Fibroblasts: Implications for Acquisition of a Matrix-remodeling Phenotype

, 2007
Shangxi Liu, Shiwen Xu, Laura Kennedy, Daphne Pala, Yunliang Chen, Mark Eastwood, David E. Carter, Carol M. Black, David Abraham, Andrew Leask   +9 more
openalex   +2 more sources

Structural maintenance of chromosome protein 1A exacerbates liver fibrosis by enhancing hepatic stellate cell activation and extracellular matrix synthesis via laminin subunit gamma 2 activation

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
Structural maintenance of chromosome protein 1A activates the PI3K/Akt signaling pathway by promoting laminin subunit gamma 2 transcription, which facilitates hepatic stellate cell activation and extracellular matrix deposition, leading to liver fibrosis progression.
Dandan Wang, Ning Li, Ranyan Gao, Jiaxin Wang, Lingyi Xu, Fengchun Li, Xinyu Geng, Ram Prasad Chaulagain, Babalola Deborah Oluwaseun, Xiaoyu Zhang, Shuang Jin, Shizhu Jin   +11 more
wiley   +1 more source

[Retracted] Growth and differentiation factor‑9 promotes adhesive and motile capacity of prostate cancer cells by up‑regulating FAK and Paxillin via Smad dependent pathway. [PDF]

Oncol Rep
Bokobza SM, Ye L, Kynaston HG, Jiang WG.
europepmc   +1 more source

Combination effect of flavonoids attenuates lung cancer cell proliferation by inhibiting the STAT3 and FAK signaling pathway [PDF]

Pei Wan, Xingru Li, Shiqi Guo, Xiangling Zhao   +3 more
openalex   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

VS-4718 enhances apoptosis induced by low-dose carfilzomib and overcomes carfilzomib resistance in PSMB5-mutated proteasome inhibitor resistant multiple myeloma. [PDF]

Sci Rep
Leich-Zbat E, Heredia-Guerrero SC, Evers M, Stühmer T, Grieb T, Rauert-Wunderlich H, Bargou RC, Rosenwald A, Chatterjee M, Brünnert D.   +9 more
europepmc   +1 more source

The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status.

, 2012
Sylvia E. Le Dévédec, Bart Geverts, Hans de Bont, Kuan Yan, Fons J. Verbeek, Adriaan B. Houtsmuller, Bob van de Water   +6 more
openalex   +2 more sources

Ninjurin1 in cardiovascular and vascular biology: From molecular mechanisms to therapeutic opportunities

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
NINJ1 mediates PMR in cardiovascular cell death, releasing DAMPs that amplify vascular inflammation. Dual NINJ1 paradox: membrane‐bound form drives endothelial NF‐κB/CXCL‐8 inflammation while soluble form provides atheroprotection. Pericyte NINJ1 regulates the critical balance between angiogenic sprouting and vessel maturation in ischaemic tissues ...
Muhammad Mamunur Rashid Mahib
wiley   +1 more source