Results 231 to 240 of about 219,223 (326)

From Pharmaceutical to Biophysical Therapies: New Horizons in Inflammatory Bowel Disease Management

JCC Plus, Volume 1, Issue 2, March 2026.
Important limitations exist in the current pharmacological landscape of Inflammatory Bowel Disease (IBD), such as variable response rates and treatment‐limiting adverse effects. In this review, we perform a critical assessment of the current literature on novel multimodal biophysical approaches showing alternative mechanisms of action to, and potential
Benedetta Ricchi, Alejandra A. Carriles, Samuel Elias Pineda Chavez, Stefanos Bonovas, Arianna Dal Buono, Cristina Bezzio, Alessandro Armuzzi, Stefania Vetrano   +7 more
wiley   +1 more source

Context-specific targeting of focal adhesion kinase in brain tumors: lessons from glioblastoma and neurofibromatosis type 2-mutant meningioma. [PDF]

Front Oncol
Sagerer A, Eyüpoglu IY, Juratli TA, Cordes N.   +3 more
europepmc   +1 more source

Podocyte‐Derived Extracellular Vesicles Induce Endothelial Dysfunction by Triggering ER Stress in Glomerular Disease

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Podocyte injury and endothelial cell dysfunction are the hallmarks of glomerular disease. How these two events are connected remains largely unknown. This study aimed to delineate the role of extracellular vesicles (EVs) in mediating podocyte‐endothelial communication in glomerular disease.
Zhao Liu, Xi Liu, Xin Wen, Siyu Yan, Meizhi He, Jie Xu, Zhanji Zhan, Haili Zhu, Huishi Tan, Nan Jia, Youhua Liu   +10 more
wiley   +1 more source

Focal Adhesion and Cancer Cell Cycle-Associated Resistance. [PDF]

ACS Omega
Ruksha TG, Palkina NV, Lapkina EZ, Liu K.   +3 more
europepmc   +1 more source

The function of FAK/CCDC80/E‑cadherin pathway in the regulation of B16F10 cell migration

, 2018
Guoshun Pei, Yan Lan, Weijie Lu, Lina Ji, Zichun Hua   +4 more
openalex   +2 more sources

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology

Journal of Neuroscience Research, Volume 104, Issue 3, March 2026.
Chondroitin sulfate proteoglycans (CSPGs) are critical components of the extracellular matrix in the central nervous system (CNS). In the developing CNS, CSPGs regulate neural precursor cells, neuronal migration, axon guidance, synapse organization, and peri‐neuronal net assembly.
Seyed Mojtaba Hosseini, Soheila Karimi‐Abdolrezaee   +1 more
wiley   +1 more source

EIF4A3/circPTGR1/miR-4725-5p positive- feedback loop promotes colorectal cancer progression via FAK/AKT signaling pathway. [PDF]

Mol Cancer
Dong Y, Ding YH, Yang X, Song XH, Lei XT, Tang YN, Zhang XE, Huang WC, Zhang K, Chen JS.   +9 more
europepmc   +1 more source

Repeated (Weekly) Intra‐Articular Injections of Sulfated Galactans Attenuate Cartilage Degeneration in a Rat Model of Osteoarthritis

Journal of Orthopaedic Research, Volume 44, Issue 3, March 2026.
Knee osteoarthritis (OA) is characterized by progressive cartilage degeneration and remains a major cause of joint dysfunction with limited disease‐modifying therapies. This study evaluated the therapeutic potential of sulfated galactans (SG) extracted from Gracilaria fisheri in a rat OA model induced by anterior cruciate ligament transection and ...
Nirada Srianake, Amarin Thongsuk, Scarlett Desclaux, Thitiya Phuagpan, Jiraporn Sriwong, Alita Kongchanagul, Wanwisa Himakhun, Ruedee Hemstapat, Kanokpan Wongprasert   +8 more
wiley   +1 more source

Thrombomodulin facilitates melanoma progression via FAK- and ezrin-mediated phenotypic plasticity. [PDF]

J Biomed Sci
Kuo CH, Sie RH, Ku YC, Wu CL, Hsu CK, Lai CH, Wu HL.   +6 more
europepmc   +1 more source

Assessment of the in vitro metabolic stability of CEP-37440, a selective FAK/ALK inhibitor, in HLMs using fast UPLC–MS/MS method: in silico metabolic lability and DEREK alerts screening [PDF]

Mohamed W. Attwa, Haitham AlRabiah, Ali S. Abdelhameed, Adnan A. Kadi   +3 more
openalex   +1 more source