Results 241 to 250 of about 219,223 (326)

Single‐Cell Transcriptomic Analysis Reveals Epithelial‐Mesenchymal Transition and Key Gene AGRN as a Universal Programme in Gastrointestinal Tumours by an Artificial Intelligence‐Derived Prognostic Index

Med Research, Volume 2, Issue 1, Page 41-57, March 2026.
Intra‐tumour heterogeneity is present in gastrointestinal tumours at the single‐cell level. Cell cycling, EMT, MYC and TNF‐α are the four main consensus meta‐programs in gastrointestinal tumours. Then, a prognostic model based on intratumoral heterogeneity was constructed using an artificial intelligence‐derived prognostic index.
Zhizhan Ni, Pengyuan Zhu, Liming Liu, Haiyang Wang, Jinzhe Zhou, Xianqing Wang, Song Wang, Liangchen Zhu, Songze Zhang, Yongxin Zhou, Bujun Ge, Qi Huang, Chenshen Huang   +12 more
wiley   +1 more source

COL8A1 promotes prostate cancer progression via modulating tumor immune infiltration and activating the FAK/PI3K/AKT pathway through ADAMTS2 regulation. [PDF]

Sci Rep
Wang J, Ning J, Xu L, Cheng F.
europepmc   +1 more source

FAK signaling suppression by OCT4-ITGA6 mediates the effectively removal of residual pluripotent stem cells and enhances application safety [PDF]

Wenpeng Song, Jian Song, Shixin Gong, Xiaoyan Wang, Junji Xu, Ruiqing Wu, Zongmin Jiang, Huiyuan Zhang, Li‐Da Wu, Yilong Wang, Yingying Su, Hao Wang, Yuchun Gu   +12 more
openalex   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

FAK-Activated Mucosal Healing Promotes Resistance to Reinjury. [PDF]

Cells
Oncel S, Liu G, Kwantwi L, Vomhof-DeKrey EE, Gallardo-Macias R, Gurvich VJ, Basson MD.   +6 more
europepmc   +1 more source

Evaluation of anti-liver cancer activity and anticancer mechanism of one novel small molecule compound (THY-10A62) targeting FAK pathway [PDF]

Wanqiu Huang, Rong Zou, Jie Xu, Yuliang Deng, Dongping Zhang, Yiguo Hu, Qian Zhang, Jian Huang, Zhaoqi Zhang   +8 more
openalex   +1 more source

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Macrophage extracellular traps amplify retinal endothelial anoikis via the S1P-S1PR axis in diabetic retinopathy. [PDF]

J Transl Med
Song Y, Li H, Feng L, Liu G, Wang F, Liao X, Li M.   +6 more
europepmc   +1 more source

Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs

, 2019
Hongying Gao, Yue Wu, Yonghui Sun, Yiqing Yang, Guang‐Biao Zhou, Yu Rao   +5 more
openalex   +2 more sources

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source