Results 251 to 260 of about 219,223 (326)

Focal adhesion kinase inhibition enhances response to checkpoint immunotherapy in hepatocellular carcinoma. [PDF]

J Transl Int Med
Liu X, Wang F, Cui P, Zheng Z, Zhang N, Kong R.   +5 more
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Polydopamine-Coated Surfaces Promote Adhesion, Migration, Proliferation, Chemoresistance, Stemness, and Epithelial-Mesenchymal Transition of Human Prostate Cancer Cell Lines In Vitro via Integrin α₂β₁-FAK-JNK Signaling. [PDF]

Int J Mol Sci
Song WH, Kim JE, Rajbongshi L, Lee SR, Kim Y, Hwang SY, Oh SO, Kim BS, Lee D, Yoon S.   +9 more
europepmc   +1 more source

SPP1 promotes ovarian cancer progression via Integrin β1/FAK/Akt signaling pathway

, 2018
Biao Zeng, Min Zhou, Haoran Wu, Z Xiong
openalex   +1 more source

T‐Cell Signaling Pathways, Including Exhaustion, Predominate in Unhealthy Visceral and Subcutaneous Adipose Tissues

Obesity, Volume 34, Issue 3, Page 674-685, March 2026.
ABSTRACT Objective Obesity is an imperfect correlate of metabolic health. Visceral adipose tissue (VAT) characteristics are considered determinants of poor health and subcutaneous adipose tissue (SAT) considered protective. There is a gap in knowledge regarding shared vs.
Sobha Puppala, Alyssa R. Hamann, Christina M. Stevens, Alistaire Ruggiero, Laura A. Cox, Kylie Kavanagh   +5 more
wiley   +1 more source

The FN1-ITGB4 Axis Drives Acquired Chemoresistance in Bladder Cancer by Activating FAK Signaling. [PDF]

Oncol Res
Zhang X, Zong R, Sun Y, Chen N, Zhu K, Tong H, Li T, Zhu J, Qin Z, Wu L, Wang A, He W.   +11 more
europepmc   +1 more source

FAK Kinase Activity Is Required for the Progression of c-MET/β-Catenin-Driven Hepataocellular Carcinoma

, 2016
Na Shang, Maribel Arteaga, Ali H. Zaidi, Scott J. Cotler, Peter Breslin, Xianzhong Ding, Paul C. Kuo, Michael I. Nishimura, Jiwang Zhang, Wei Qiu   +9 more
openalex   +2 more sources

JANEX-1 improves acute pulmonary embolism through VEGF and FAK in pulmonary artery smooth muscle cells

, 2020
Longfei Pan, Zhuo Peng, Ruipeng Zhang, Rui Zhang, De-an Liang, Heming Chen, Hongyan Tian   +6 more
openalex   +2 more sources

Engineering Nanocellulose Scaffolds: Property Modification Strategies and Mechanotransduction‐Driven Tissue Outcomes

Polymers for Advanced Technologies, Volume 37, Issue 3, March 2026.
ABSTRACT Nanocellulose is being increasingly used in biomedical applications because of its biocompatibility, mechanical robustness, tunable surface chemistry, and adjustable rheology. This review evaluates recent strategies for engineering cellulose nanofibrils, nanocrystals, and bacterial nanocellulose into cell‐instructive scaffolds for skin, bone ...
Aurora Rodríguez Martínez, Aleida Nuñez Ruiz, Gloria Soldevila, Alejandro Elizalde Cárdenas, Guadalupe Antonio Ríos, Rosa María Ribas Aparicio, Maykel González Torres   +6 more
wiley   +1 more source

Establishing selectivity of FAK-paxillin PPI inhibitor using pulldown proteomics and a focal adhesion protein selectivity panel. [PDF]

Biochem Biophys Rep
O'Brien H, Hay B, Sheikh H, McCreary L, Parsawar K, Marlowe T.   +5 more
europepmc   +1 more source