Results 51 to 60 of about 5,617,819 (244)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
How Does ChatGPT Affect Fake News Detection Systems?
, 2023 Artificial Intelligence technology has been constantly advancing and becoming more noticeable in various areas of our daily lives. One remarkable instance is the creation of a chatbot named ChatGPT (Chat Generative Pre-trained Transformer), which has a ...
Ju, J, Wang, C, Li, B, Pan, S
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
UNVEILING FAKE NEWS DETECTION MODELS AND THEIR INTEGRATION INTO WEB SYSTEMS: AN EXTENSIVE INVESTIGATION [PDF]
Proceedings on Engineering SciencesThe pervasive spread of fake news poses a critical threat to information integrity, demanding swift and innovative countermeasures. Addressing this challenge, Fake News Detection System, a user-friendly web application, utilizes advanced natural language
Vimal Gaur +3 more
doaj +1 more source
Detecting fake news on Facebook: The role of emotional intelligence.
PLoS ONE, 2021 The proliferation of fake news on social media is now a matter of considerable public and governmental concern. In 2016, the UK EU referendum and the US Presidential election were both marked by social media misinformation campaigns, which have ...
Stephanie Preston +4 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
A Review of Methodologies for Fake News Analysis
IEEE Access, 2023 Nowadays, with the proliferation of different news sources, fake news detection is becoming a crucial topic to research. Millions of articles are published daily in the press, on social media, and in electronic media, and many of them may be fake.
Mehedi Tajrian +3 more
doaj +1 more source