Results 61 to 70 of about 53,465 (250)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

CSI: A Hybrid Deep Model for Fake News Detection

open access: yes, 2017
The topic of fake news has drawn attention both from the public and the academic communities. Such misinformation has the potential of affecting public opinion, providing an opportunity for malicious parties to manipulate the outcomes of public events ...
Liu, Yan   +2 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Automatic Stance Detection Using End-to-End Memory Networks

open access: yes, 2018
We present a novel end-to-end memory network for stance detection, which jointly (i) predicts whether a document agrees, disagrees, discusses or is unrelated with respect to a given target claim, and also (ii) extracts snippets of evidence for that ...
Baly, Ramy   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

UNVEILING FAKE NEWS DETECTION MODELS AND THEIR INTEGRATION INTO WEB SYSTEMS: AN EXTENSIVE INVESTIGATION [PDF]

open access: yesProceedings on Engineering Sciences
The pervasive spread of fake news poses a critical threat to information integrity, demanding swift and innovative countermeasures. Addressing this challenge, Fake News Detection System, a user-friendly web application, utilizes advanced natural language
Vimal Gaur   +3 more
doaj   +1 more source

Detecting fake news on Facebook: The role of emotional intelligence.

open access: yesPLoS ONE, 2021
The proliferation of fake news on social media is now a matter of considerable public and governmental concern. In 2016, the UK EU referendum and the US Presidential election were both marked by social media misinformation campaigns, which have ...
Stephanie Preston   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Team QCRI-MIT at SemEval-2019 Task 4: Propaganda Analysis Meets Hyperpartisan News Detection

open access: yes, 2019
In this paper, we describe our submission to SemEval-2019 Task 4 on Hyperpartisan News Detection. Our system relies on a variety of engineered features originally used to detect propaganda.
Baly, Ramy   +6 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

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