Results 71 to 80 of about 16,415 (206)

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, Volume 30, Issue 3, Page 371-376, June 2026.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

A Case of Carcinosarcoma of the Peritoneum With Serous Tubal Intraepithelial Carcinoma

Case Reports in Obstetrics and Gynecology
In this case, a 66-year-old female patient presented with the chief complaint of abdominal distention. Computed tomography and magnetic resonance imaging revealed no enlarged ovaries or obvious primary lesions; however, massive ascites and peritoneal ...
Akiko Kanemura, Tohru Morisada, Mai Momomura, Fumio Asano, Hiromi Shibuya, Hironori Matsumoto, Kiyotaka Nagahama, Junji Shibahara, Yoichi Kobayashi   +8 more
doaj   +1 more source

Primary neuroendocrine carcinoma of the fallopian tube with exceeding 10 years follow-up: Case report and review of the literature

Gynecologic Oncology Reports
Neuroendocrine carcinomas typically originate from the digestive system and lungs; however, their occurrence in the female genital tract, particularly in the fallopian tube, is exceedingly rare.
Jun Ma, Yujing Tang, Wei He, Jun Shi
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, Volume 20, Issue 6, Page 1535-1555, June 2026.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A case analysis of primary fallopian tube carcinoma

, 2014
目的  探讨原发性输卵管癌的诊断，减少漏诊率的发生。方法  复习1例原发性输卵管癌的临床资料，分析原发性输卵管癌漏诊的原因及在诊断中容易忽视的几个环节。结果  根据患者诊刮病理提示为子宫内膜中分化腺癌，未考虑输卵管癌的可能，术中忽视输卵管的改变，未送快速冰冻切片检查，因此导致漏诊。结论  输卵管癌发病率较低，患者症状表现不典型，盆腔未发现包块，医生警惕性不够，根据诊刮病理结果形成了先入为主的观念，以致术中亦忽略了剖视输卵管。因此对于考虑子宫内膜癌的患者，应警惕输卵管癌的可能。Objective: To ...
Jiang, Ling; Gynecology of The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicince, Guangzhou Guangdong, China
core   +1 more source

A Case of Malignant Brenner Tumor With High FDG Uptake

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Malignant Brenner Tumor (MBT) is a rare malignant neoplasm originating from the ovarian surface epithelium. This type of tumor typically lacks specific clinical manifestations and dedicated tumor markers. In our case, we present a complete set of clinical information, diagnosis and treatment protocols, and follow‐up results of one case of MBT.
Jie Li, Longdong Fang, Tian‐yun Wang, Jin‐gang Hao   +3 more
wiley   +1 more source

Unexpected primary fallopian tube carcinoma during gynecological operations: Clinicopathological and prognostic factors analyses of 67 cases

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: The aim of the study was to analyze the clinicopathologic features, the survival rate, and the prognostic factors of women with unexpected primary fallopian tube carcinoma diagnosed during gynecological operations.
Mingming Sun, Lingjie Bao, Haoran Shen, Min Ji, Liangqing Yao, Xiaofang Yi, Wei Jiang   +6 more
doaj   +1 more source

Integrating antibody–drug conjugates into solid tumor oncology: Current standards and future directions

Cancer, Volume 132, Issue S1, 1 June 2026.
Abstract Antibody–drug conjugates (ADCs) represent a major advance in precision oncology, combining the selectivity of monoclonal antibodies with the cytotoxic potency of chemotherapy. By enabling targeted intracellular delivery of highly potent payloads, ADCs aim to maximize antitumor activity while minimizing systemic toxicity. This review summarizes
André Mansinho, Joana Albuquerque, Andreia Lopes, Emiliano Calvo   +3 more
wiley   +1 more source

BRCA mutation in high grade epithelial ovarian cancers

Gynecologic Oncology Reports, 2019
Objective: To identify the frequency of BRCA mutation in patients with high grade epithelial ovarian cancer (EOC). Methods: Patients with EOC included fallopian tube cancer or peritoneal cancer with high grade serous or high grade endometrioid were ...
Tarinee Manchana, Natacha Phoolcharoen, Patou Tantbirojn   +2 more
doaj   +1 more source