Results 111 to 120 of about 200 (180)

Genomic, Trop‐2, and Immune Profiles of Carcinomatous and Sarcomatous Components in Ovarian Carcinosarcoma

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background Ovarian carcinosarcoma (OCS) is a rare, aggressive tumor composed of both carcinomatous and sarcomatous components, typically associated with poor prognosis. Due to its rarity, the molecular characteristics, immune microenvironment, and optimal treatment of OCS remain unclear.
Tomomi Sakamaki, Tatsuyuki Chiyoda, Kohei Nakamura, Reika Takamatsu, Ryutaro Kawano, Daisuke Ochiai, Mitsuyo Jisaka, Mio Takahashi, Takuma Yoshimura, Yumiko Kimura, Shinya Oki, Kensuke Sakai, Tomoko Yoshihama, Hiroshi Nishihara, Wataru Yamagami   +14 more
wiley   +1 more source

Germline predisposition and somatic mutational landscape in synchronous mucinous metaplasia and neoplasia of the female genital tract

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN‐FGT) is characterised by an enrichment of pathogenic germline variants in cancer‐predisposition genes, particularly BRCA1 and other homologous recombination repair genes. Recurrent TP53 mutations are concentrated in malignant lesions, while clonal and functional analyses ...
Ying Yuan, Li Zhang, Jiongbo Liao, Bo Wang, Linghui Lu, Dongchen Chu, Yue Shi, Jiaqi Liu, Feng Zhang, Shuyan Tang, Chao Wang   +10 more
wiley   +1 more source

Inverse association between obesity and intestinal endometriosis: Findings from a cross‐sectional study

International Journal of Gynecology &Obstetrics, Volume 174, Issue 2, Page 1044-1049, August 2026.
Abstract Objective This study evaluates the association between obesity and the presence of bowel endometriosis in patients undergoing surgery. Methods A retrospective cross‐sectional observational study was conducted with patients treated between September 2023 and December 2024, at a specialized endometriosis outpatient clinic of a tertiary hospital ...
Tereza Carolina Fonseca Corrêa, Marco Aurelio Pinho Oliveira   +1 more
wiley   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, Volume 78, Issue 8, Page 959-966, August 2026.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Understanding risk perception and risk‐reducing decision‐making for surgery among individuals with a genetic predisposition to epithelial ovarian cancer

Journal of Genetic Counseling, Volume 35, Issue 4, August 2026.
Abstract Genetic predisposition to hereditary breast and ovarian cancer and Lynch syndrome increases the risk of developing cancer, including epithelial ovarian cancer (EOC). Depending on the pathogenic variant, (e.g., BRCA1 or PMS2) the risk of developing EOC ranges from approximately 3%–60%.
Rebekah Kukurudz‐Gorowski, Sylvia Horn, Pascal Lambert, Kim Serfas, Renée El‐Gabalawy, Alon David Altman, Kirk James McManus, Jessica Nicole Hartley, Mark William Nachtigal   +8 more
wiley   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng, Shuiquan Li, Zhigang Zhang, Mengke Niu, Jing Fei, Jiaojiao Zhang, Jianwei Zhou, Kongming Wu, Ming Yi, Tianye Li   +9 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Primary Ciliary Dyskinesia: A Suggested Pathway to Transition From Pediatric to Adult Care

Pediatric Pulmonology, Volume 61, Issue 8, August 2026.
ABSTRACT Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous disorder characterized by motile ciliary dysfunction that impairs mucociliary clearance. Symptoms of PCD can include unexplained neonatal respiratory issues, chronic sino‐otopulmonary symptoms, recurrent infections, bronchiectasis, and subfertility.
Abel De Castro, Melanie Sue Collins, Raksha Jain, Jennifer B. Walsh, Juliana Alba‐Suárez, Yadira M. Rivera‐Sánchez   +5 more
wiley   +1 more source

Prospective external validation of ADNEX and RMI for estimating risk of malignancy in adnexal masses in general gynecological settings: Danish multicenter study

Ultrasound in Obstetrics &Gynecology, Volume 68, Issue 2, Page 256-269, August 2026.
ABSTRACT Objectives The primary aims of this study were to validate externally the diagnostic performance of the Assessment of Different NEoplasias in the adneXa (ADNEX) model for distinguishing between malignant and benign adnexal masses, when used by non‐expert ultrasound examiners in general gynecological settings with a low prevalence of ovarian ...
I. M. Dueholm Hjorth, B. H. Bech, A. Ledger, C. Møller, T. Van den Bosch, O. Mogensen, Collaborators, R. Al Taie, C. Blach Kristensen, M. Lundegaard Iversen, P. Bor, M. Stentebjerg   +11 more
wiley   +1 more source

The Impact of the Vaginal Microbiome and Microbial Metabolites on HIV Transmission at the Female Reproductive Tract Epithelial Barrier

American Journal of Reproductive Immunology, Volume 96, Issue 2, August 2026.
ABSTRACT Despite major advances in biomedical HIV prevention strategies, almost 50% of the 1.3 million new HIV infections in 2024 occurred in women and girls through heterosexual transmission. Choice in HIV prevention modalities is needed throughout a women's lifespan to increase pre‐exposure prophylaxis uptake; however, there is a paucity of topical ...
Brianna Jesaveluk, Paula Ellenberg, Anna C. Hearps, Gilda Tachedjian   +3 more
wiley   +1 more source