Results 81 to 90 of about 14,575 (205)

Experiences of Women and Clinicians During the Introduction of Uterine Transplantation to the UK: A Qualitative Case Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To explore the experiences of women and clinicians during the introduction of uterine transplantation (UTx) to the UK. Design A qualitative study utilising prospective case study methodology (interviews and observations) over 6 years.
Daisy Elliott, Richard J. Smith, Maeve Coyle, Rhiannon Macefield, Saliha Vali, Anni King, Natalie Blencowe, Cynthia Ochieng, Christin Hoffmann, Isabel Quiroga, Ben P. Jones, Ariadne L'Heveder, Kerry N. L. Avery, Jane M. Blazeby   +13 more
wiley   +1 more source

Mutational Signature‐Based Biomarker for Phase II Trial of Olaparib Maintenance in Advanced High‐Grade Ovarian Cancer

Cancer Science, EarlyView.
A whole‐exome sequencing–based mutational signature biomarker (MSBM) identified an HRD‐enriched population in advanced ovarian cancer. In a phase II trial, olaparib maintenance suggested clinically meaningful PFS benefit without bevacizumab, supporting MSBM as a complementary HRD assessment approach.
Katsutoshi Oda, Daisuke Shintani, Akira Nishijima, Mayuyo Mori, Kazuyoshi Kato, Shoji Nagao, Noriomi Matsumura, Masahiro Kagabu, Masataka Takenaka, Kosuke Yoshihara, Yosuke Konno, Junzo Hamanishi, Sho Sato, Shiro Takamatsu, Keiko Ueda, Kosuke Kashiwabara, Takashi Aoki, Kunihiro Nishimura, Kenji Tatsuno, Hiroyuki Aburatani, Kosei Hasegawa   +20 more
wiley   +1 more source

Kiaušintakio gerybiniai intraepiteliniai pokyčiai: klinikinis atvejis ir mokslinės literatūros apžvalga [PDF]

Serous tubal intraepithelial lesion (STIL) is a rare benign lesion of the fallopian tube epithelium characterized by atypical epithelial cells with morphological anomalies, marked by the accumulation of p53 protein and normal or slightly increased ...
Tretjakova, Ksenija, Bužinskienė, Diana   +1 more
core   +2 more sources

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

Metaplastic papillary tumour of the salpinx: report of a case with microsatellite analysis [PDF]

, 2011
Metaplastic papillary tumour (MPT) of the salpinx is a rare lesion found in the lumen of Fallopian tubes during the post-partum period. This lesion is very small and microscopically is composed of papillae lined by stratified epithelium.
AZZONI, Cinzia, Silvia Pizzi, Lorena Bottarelli, PIZZI, Silvia, S. Manni, Tiziana DʼAdda, GIORDANO, Giovanna, Stefania Manni, Giovanna Giordano, D'ADDA, Tiziana, Cinzia Azzoni, BOTTARELLI, Lorena   +11 more
core   +1 more source

Phase II Trial of Nivolumab in Advanced Solid Tumors Based on Genomic Profiling: BELIEVE Trial (NCCH1901) Subcohort

Cancer Science, EarlyView.
Off‐label nivolumab treatment guided by CGP results was evaluated in 56 patients with advanced solid tumors. TMB‐High was the predominant biomarker leading to nivolumab treatment. Nivolumab showed limited clinical benefit in 50 patients with measurable disease, with an ORR of 16.0%, DCR of 40.0%, median PFS of 2.7 months, and median OS of 7.2 months ...
Masashi Kanai, Kuniko Sunami, Tatsunori Shimoi, Satoshi Nishiwaki, Ichiro Kinoshita, Tetsuhiro Yoshinami, Chigusa Morizane, Yusuke Sato, Toshio Kubo, Mamoru Ito, Hiroshi Nishihara, Toru Mukohara, Hidekazu Shirota, Ryo Ko, Taro Shibata, Manabu Muto, Noboru Yamamoto   +16 more
wiley   +1 more source

Comprehensive Histopathological Profiling of Female Genital Tract Neoplasms: Insights from a Two-Year Prospective Study

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Introduction: Neoplasms of the female genital tract show considerable histopathological diversity, with leiomyomas being the most frequent benign tumors and carcinomas of the endometrium, cervix, and ovary representing significant malignant entities ...
Shirish S. Chandanwale, Abhishek Tambile, Madhuri Singh Akshi Raj, Nandita Wadhwa, Ranjana Roy   +4 more
doaj   +1 more source

Advancing collagen‐related pathology assessment through second‐harmonic generation imaging

Journal of Microscopy, EarlyView.
Abstract Collagen remodelling and dysregulation are the hallmarks of diverse pathological conditions. In this context, second‐harmonic generation (SHG) imaging has emerged as a powerful label‐free modality for assessing collagen. This offers submicron resolution, intrinsic optical sectioning, and deeper imaging capabilities without the need for ...
Jackson Rodrigues, Manikanth Karnati, Gagan Raju, Edwin Pious, Ankur Gogoi, Guan‐Yu Zhuo, Nirmal Mazumder, Fu‐Jen Kao   +7 more
wiley   +1 more source

Abstract 5480: Expression and function of EVI1 and EVI1s (Δ324) ovarian cancer [PDF]

, 2010
Objective: The MDS1 and EVI1 complex locus (MECOM) located at the 3q26 locus is amplified in many cancers and gives rise to a number of alternatively spliced transcripts and proteins including EVI1 and MDS1-EVI1 (ME).
Susan Dalton, Anindya Dutta, Amir A. Jazaeri, Yuichi Machida, Jennifer L. Bryant, James S. Ferriss   +5 more
core   +1 more source

Guidance for Specialised Cancer Nursing of People With Gynaecological Cancers: A Scoping Review

Journal of Clinical Nursing, EarlyView.
ABSTRACT Background Gynaecological cancer nurses are crucial to the delivery of quality, specialised care to meet the needs of people with these cancers. The extent of evidence‐based guidance to support nursing care is unknown. Aim To identify and describe existing international guidance for specialised gynaecological cancer nursing care.
Natalie Williams, Georgia Halkett, Tracey Moroney, Sharon MacLean, Olivia Cook   +4 more
wiley   +1 more source