Results 61 to 70 of about 3,110,356 (288)

Patch-Based convolutional neural networks for multiple microstructural features detection in FIB-SEM micrographs of irradiated nuclear fuel

Scientific Reports
Focused ion beam scanning electron microscopy (FIB-SEM) tomography has increasingly been utilized for acquiring three-dimensional (3D) microstructure features at the sub-micron scale in irradiated nuclear materials. This technique involves sequential ion
Jason Uwaeze, Yalei Tang, Tanner Jason Mauseth, Vladimir Braverman, Matthew William Anderson, Yachun Wang, Fei Xu   +6 more
doaj   +1 more source

Relationship between captive bolt placement, tissue parameters, and brain contact in cadaver heads from culled Holstein cows >30 mo of age

Journal of Dairy Science
: Penetrating captive bolt (PCB) is a method of euthanasia and preslaughter stunning for cattle. Industry guidelines include multiple PCB locations with minimal scientific justifications.
Karly N. Anderson, Ruth Woiwode, Emma M. Hamilton, Ashlynn A. Kirk, Maryn J. Cowell, Arquimides A. Reyes, Perle E. Zhitnitskiy, Kurt D. Vogel   +7 more
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

The Victoria Falls, a species boundary for the Zambezi Parrotfish, Cyphomyrus discorhynchus (Peters, 1852), and the resurrection of Cyphomyrus cubangoensis (Pellegrin, 1936) (Mormyridae: Teleostei) [PDF]

, 2011
Cyphomyrus discorhynchus occurs in the Zambezi River and in the linked systems of the Kwando and the Okavango. We collected specimens from both above and below the Victoria Falls and recorded Electric Organ Discharges.
Kramer, Bernd, Van der Bank, F. Herman
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Design and development of a theory-informed peer-led falls prevention education programme to translate evidence into practice: A systematic approach [PDF]

, 2018
Peer-led education has been shown to be an effective approach for raising community-dwelling older adults’ beliefs, knowledge and intention to engage in falls prevention strategies in a recent intervention trial.
Berlach, Richard G, Hill, Anne-Marie, Hill, Keith D, Khong, Linda   +3 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Physical and functional characterization of whey protein-lignin biocomposite films for food packaging applications

Future Foods
Whey protein isolate (WPI) and lignin are by-products of the cheese production and pulp and paper industries, respectively. The objective of this work was to analyze the physicochemical and mechanical properties of biodegradable films made from WPI (at ...
Yihong Deng, Sierra Kolodjski, Grace Lewis, Gary Onan, Youngmi Kim   +4 more
doaj   +1 more source