Results 61 to 70 of about 864,060 (313)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Pragmatic Randomized Clinical Trial Comparing Rectilinear Biphasic Waveform and Biphasic Truncated Exponential Waveform Shocks for Cardioversion of Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background No adequately powered prospective studies have compared the safety and efficacy of rectilinear biphasic waveform (RBW) shocks and biphasic truncated exponential (BTE) shocks for direct current cardioversion of atrial fibrillation.
Andrew H. Nguyen, Abbas Emaminia, Chirag Sandesara, Leonard Ilkhanoff, Stephen A. Gaeta, Jeff (Jae) Lee, James Duc, Adam S. Fein, Elizabeth Held, Zachary Hollis, Vineet Kumar, Robert L. McSwain, Joseph C. Lee, Aysha Arshad, Haroon Rashid, Marc H. Wish, Eunice Yang, Mutaz Alkalbani, Christopher M. O'Connor, Brett D. Atwater   +19 more
doaj   +1 more source

Adult Astrogenesis and the Etiology of Cortical Neurodegeneration

Journal of Experimental Neuroscience, 2015
As more evidence points to a clear role for astrocytes in synaptic processing, synaptogenesis and cognition, continuing research on astrocytic function could lead to strategies for neurodegenerative disease prevention.
Tal C. Mohn, Andrew O. Koob
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Patch-Based convolutional neural networks for multiple microstructural features detection in FIB-SEM micrographs of irradiated nuclear fuel

Scientific Reports
Focused ion beam scanning electron microscopy (FIB-SEM) tomography has increasingly been utilized for acquiring three-dimensional (3D) microstructure features at the sub-micron scale in irradiated nuclear materials. This technique involves sequential ion
Jason Uwaeze, Yalei Tang, Tanner Jason Mauseth, Vladimir Braverman, Matthew William Anderson, Yachun Wang, Fei Xu   +6 more
doaj   +1 more source

Falls and Fall Prevention

MedEdPORTAL, 2014
Abstract This workshop is intended to promote and enhance active learning and problem-solving among third-year medical students. At our institution, we decided to transform the existing didactic and case-based falls/fall-prevention workshop into a team-based learning (TBL) format, integrating two minimum geriatric competencies and the latest evidence ...
openaire   +2 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Relationship between captive bolt placement, tissue parameters, and brain contact in cadaver heads from culled Holstein cows >30 mo of age

Journal of Dairy Science
: Penetrating captive bolt (PCB) is a method of euthanasia and preslaughter stunning for cattle. Industry guidelines include multiple PCB locations with minimal scientific justifications.
Karly N. Anderson, Ruth Woiwode, Emma M. Hamilton, Ashlynn A. Kirk, Maryn J. Cowell, Arquimides A. Reyes, Perle E. Zhitnitskiy, Kurt D. Vogel   +7 more
doaj   +1 more source

The Fall of Bodies [PDF]

Science, 1903
n ...
openaire   +3 more sources

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source