Results 61 to 70 of about 3,131,355 (307)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Relationship between captive bolt placement, tissue parameters, and brain contact in cadaver heads from culled Holstein cows >30 mo of age

Journal of Dairy Science
: Penetrating captive bolt (PCB) is a method of euthanasia and preslaughter stunning for cattle. Industry guidelines include multiple PCB locations with minimal scientific justifications.
Karly N. Anderson, Ruth Woiwode, Emma M. Hamilton, Ashlynn A. Kirk, Maryn J. Cowell, Arquimides A. Reyes, Perle E. Zhitnitskiy, Kurt D. Vogel   +7 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

How are falls and fear of falling associated with objectively measured physical activity in a cohort of community-dwelling older men? [PDF]

, 2014
BACKGROUND: Falls affect approximately one third of community-dwelling older adults each year and have serious health and social consequences. Fear of falling (FOF) (lack of confidence in maintaining balance during normal activities) affects many older ...
AC Scheffer, B Resnick, Barbara J Jefferis, BJ Jefferis, C Sherrington, Chief Medical Officers of England SWaNI, Claudio Sartini, D Jung, DA Ganz, Denise Kendrick, DG Bruce, DP Gill, E Gorman, E Mendes da Costa, GA Zijlstra, HW van Marwijk, JL Copeland, K Delbaere, L Choi, Lucy T Lennon, M Roth, ME Lachman, ME Nelson, ME Tinetti, MG Davis, N Aguilar-Farias, N Austin, N Deshpande, N Luo, Ngaire Kerse, P Scuffham, Peter H Whincup, RG Cumming, Richard W Morris, S Clemes, S Goya Wannamethee, S Schepens, Sarah Ash, SL Murphy, SM Friedman, StataCorp, Steve Iliffe, Stewart Trost, T Masud, TJ Harris, WJ Chodzko-Zajko   +45 more
core   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Physical and functional characterization of whey protein-lignin biocomposite films for food packaging applications

Future Foods
Whey protein isolate (WPI) and lignin are by-products of the cheese production and pulp and paper industries, respectively. The objective of this work was to analyze the physicochemical and mechanical properties of biodegradable films made from WPI (at ...
Yihong Deng, Sierra Kolodjski, Grace Lewis, Gary Onan, Youngmi Kim   +4 more
doaj   +1 more source

Utilization of the Transtheoretical Model to Determine the Qualitative Impact of a Tribal FASD Prevention Program

SAGE Open, 2019
Alcohol consumption during pregnancy can lead to damaging effects on an infant’s health, including fetal alcohol spectrum disorders. Project Changing High-risk alcOhol use and Increasing Contraception Effectiveness Study (CHOICES), a program developed to
Olivia Lowrey, Kaitlyn Ciampaglio, Jamie L. Messerli, Jessica D. Hanson   +3 more
doaj   +1 more source