Results 201 to 210 of about 537,576 (336)

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Rare metabolic gene essentiality is a determinant of microniche adaptation in Eschherichia coli. [PDF]

PLoS Pathog
Ardalani O, Phaneuf PV, Krishnan J, Chauhan SM, Pride D, Zielinski DC, Monk JM, Nielsen LK, Palsson BO.   +8 more
europepmc   +1 more source

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Prion seeding activity in DNA extractions: implications for laboratory biosafety. [PDF]

Prion
Gresch SC, Morrill T, Ellis-Cramer M, Arifin M, Frank LE, Bartz JC, Schwabenlander MD, Wolf TM, Mitchell GB, Guan J, Larsen PA.   +10 more
europepmc   +1 more source

Understanding the cause of false negative β-d-glucuronidase reactions in culture media containing fermentable carbohydrate [PDF]

Letters in Applied Microbiology, 2010
C.R. Fricker, P.S. Warden, B.J. Eldred
openaire   +1 more source

Preventing intense false positive and negative reactions attributed to the principle of ELISA to re-investigate antibody studies in autoimmune diseases

, 2014
Kuniaki Terato, Tighe Christopher, Dawn Cutler, Takaki Waritani, Hiroshi Shionoya   +4 more
openalex   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Efflux pump knockout minimizes crosstalk and boosts response in transcription factor-based biosensors. [PDF]

J Biol Eng
Lee J, Yoo BH, Jeon E, Kong H, Rha E, Shin J, Lee H, Kim H, Lee DH, Kwon KK, Lee SG.   +10 more
europepmc   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Perceptions of deferred blood donors regarding false-positive screening results for infectious diseases and European blood establishment strategies. [PDF]

Vox Sang
Beckman JE, Díaz Padilla N, van der Woud A, van den Burg P, Novotny V.   +4 more
europepmc   +1 more source