Results 251 to 260 of about 5,583,624 (329)

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Use of indocyanine green fluorescence versus patent blue V dye for sentinel lymph node biopsy in early breast cancer, a randomized controlled trial. [PDF]

J Egypt Natl Canc Inst
Nida M, Abdelmoghny A, Osman AG, Abd-erRazik MA, Hanafy DM.   +4 more
europepmc   +1 more source

Allergy Diagnosis in India: Current and Future Trends. [PDF]

Cureus
Roy SR, Gupta N, Christy A, Das A, Mohan K, Moitra S, Nag P, Nagaraju K, Nagaraju K, Nagarajan S, Nakra R, Natarajan S, Poddar M, Patra VS, Rasool R, Volvoikar D, Doshi K.   +16 more
europepmc   +1 more source

Rapid detection of Kenyan tomato leaf curl virus isolates using probe-enhanced loop-mediated isothermal amplification coupled with a modified DNA extraction method. [PDF]

PLoS One
Ndudzo A, Ng'ong'a F, Avedi EK, Ateka EM.   +3 more
europepmc   +1 more source

Development of an RT-LAMP-CRISPR/Cas12a-based nucleic acid detection platform for rapid diagnosis of porcine reproductive and respiratory syndrome virus type 2. [PDF]

Vet Anim Sci
Li C, Sun C, Xu Q.
europepmc   +1 more source

Molecular characterization of norovirus false-positive results on the BioFire FilmArray gastrointestinal panel. [PDF]

J Clin Microbiol
Reed JC, Mauer C, Mack AR, Theriault EA, Tansarli GS, Fang FC, Bourassa L, Greninger AL.   +7 more
europepmc   +1 more source

A One-Pot CRISPR/Cas12a-Based Platform for Contamination-Free Nucleic Acid Amplification Detection. [PDF]

Biosensors (Basel)
Tantai W, Xu Q, Zhang W, Li Y, Liu H.
europepmc   +1 more source