Results 81 to 90 of about 726,554 (241)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
False Mirror Office. Foretaste [PDF]
This volume features a miscellanea of images taken from the architectural designs by the Genoa-based collective firm false mirror office ...
Glorialanza, Giovanni +4 more
core
Validation of a biochip array technology for multi-mycotoxins screening in Rice and other cereals
Food Chemistry AdvancesCereal grains are widely cultivated agricultural commodities, and they constitute a key source of energy. However, many of them are affected by fungal contamination, and consequently, by the presence of mycotoxin. The development of monitoring techniques
Filipa Carreiró +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Reducing False Negatives in Intelligent Intrusion Detection Decision Response System
, 2011 As soon as the Intrusion Detection System (IDS) detects any suspicious or malicious activity, it will generate alarms. Unfortunately, the triggered alarms usually are accompanied with huge number of false alarms (false-positives and false-negatives ...
Xiao Jie Liu +3 more
core +1 more source
Simultaneous control of false positives and false negatives in multiple hypotheses testing [PDF]
, 2008 Multiple hypotheses testing is concerned with appropriately controlling the rate of false positives, false negatives or both when testing several hypotheses simultaneously.
Ebrahimi, Nader
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
International Journal of Neonatal Screening, 2019 For newborn screening (NBS) of lysosomal storage diseases, programs measure enzymatic activities in dried blood spots (DBS) and, in most cases, act on samples where the measurement is below a specific cutoff value.
Bruce H. Robinson, Michael H. Gelb
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source