Results 51 to 60 of about 160,131 (301)

False-positive test results: prevalence, time trends, and factors associated with false-positive serological markers in blood donation screening

Hematology, Transfusion and Cell Therapy
Background and Objectives: False-positive serological results in blood donation screening may arise from antibody cross-reactivity, limitations in assay specificity, or low-level reactivity during early-stage infections, ultimately leading to donor ...
Lucas Kallas-Silva, Leandro Dinalli dos Santos, Valeria de Freitas Dutra, Jose Mauro Kutner, Carolina Bonet-Bub   +4 more
doaj   +1 more source

Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS

Genes and Environment, 2021
Background Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagenicity assays using human cells are
Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura, Maya Ueda, Masayuki Mishima, Kaori Matsuzaki, Akira Takeiri, Kenji Tanaka, Yuki Okada, Munehiro Nakagawa, Shuichi Hamada, Akihiko Kajikawa, Hiroshi Honda, Jun Adachi, Kentaro Misaki, Kumiko Ogawa, Masamitsu Honma   +29 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Avaliação da interferência analítica de fármacos na determinação de proteínas e cetonas no exame químico de urina: estudos in vitro e in vivo [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Farmácia.Interferências de fármacos em análises laboratoriais podem levar a resultados incorretos, diagnósticos equivocados e ...
Silva, Adriana Scotti da
core  

General false positive ELISA reactions in visceral leishmaniasis. Implications for the use of enzyme immunoassay analyses in tropical Africa. [PDF]

, 2016
Leishmaniasis is a neglected disease in tropical countries. Clinical and laboratory features may mimic auto immune diseases and this can complicate the Leishmania diagnosis.
Elshafie, Amir, Rönnelid, Johan,, Elshafie, Amir I., Elshafie, Amir,, Rönnelid, Johan, Mullazehi, Mohammed,, Mullazehi, Mohammed   +6 more
core   +1 more source

False positive hepatitis B surface antigen after recent vaccination in pregnancy: a diagnostic pitfall

Microbes, Infection and Chemotherapy
We report the case of a 38-year-old pregnant woman who presented with a reactive hepatitis B surface antigen (HBsAg) during routine prenatal screening.
Jorge L. Hurtado-Alegre, Jorge del Piero Alvarez-Canto, Jhonatan M. Crispin-Ayala, Jhosef F. Quispe-Pari   +3 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

False-positive reaction between syphilis and hepatitis C infection [PDF]

, 1997
There are limited data about false-positive reactions against hepatitis C virus (HCV) in syphilitic patients and false-positive reactions against syphilis in the patients with HCV infection, The aim of this study was to demonstrate the false-positivity ...
Sahin, Kazim, Sonmez, Emine, ÖZBİLGE, Hatice, Kizilkaya, Nedim, Senol, Mustafa, Ozerol, Halil İbrahim   +5 more
core  

PECULIARITIES OF CONTROL OF HUMAN ALBUMIN DRUGS ON THE CONTENT OF BACTERIAL ENDOTOXINS

Разработка и регистрация лекарственных средств, 2019
The problem was considered to determine bacterial endotoxins in human albumin drugs. To improve the safety of medicines the option of dual control was recommended, which includes the rabbit pyrogen test and determining bacterial endotoxins by the LAL ...
T. V. Kukunina, A. G. Israfilov, M. L. Romanenkova, R. S. Gaynullina, L. G. Fedko   +4 more
doaj  

REGULATORY AND METHODOLOGICAL ASPECTS OF STUDYING ALLERGENIC PROPERTIES OF NEW MEDICINES AT THE PRECLINICAL STAGE

Регуляторные исследования и экспертиза лекарственных средств, 2018
The assessment of allergic risk at the preclinical stage of drug development has been a debatable issue due to the integration of national requirements for medicines authorisation with those of the Eurasian Economic Union (EAEU).
K. L. Kryshen, A. E. Katelnikova, A. A. Muzhikyan, M. N. Маkarova, V. G. Makarov   +4 more
doaj   +1 more source