Results 51 to 60 of about 3,555,724 (288)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Sensors, 2021 Interrupted sampling repeater jamming (ISRJ) is an effective method for implementing deception jamming on chirp radars. By means of frequency-shifting jamming processing of the target echo signal and pulse compression during image processing, a group of ...
Zhidong Liu, Qun Zhang, Kaiming Li
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Radar False Alarm Suppression Based on Target Spatial Temporal Stationarity for UAV Detecting
DronesDue to its ease of implementation without an additional transmitter, radar communication integrated systems using conventional communication signals have become an effective means for monitoring unmanned aerial vehicles and other aircraft. However, their
Chunlin Sun +3 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Variable pulse width dexterous jamming based on chaotic sampling fusion [PDF]
Zhihui kongzhi yu fangzhenAiming at the problem of strong distribution regularity of false targets in traditional repetitive repeater deception jamming, this paper proposes a variable pulse width smart jamming method based on intermittent chaotic sampling from the perspective of ...
WANG Guoxuan, YE Zijie
doaj +1 more source
Evaluation of false positive and false negative errors in targeted next generation sequencing
Genome BiologyAbstract Background Although next generation sequencing (NGS) has been adopted as an essential diagnostic tool in various diseases, NGS errors have been the most serious problem in clinical implementation.
Youngbeen Moon +10 more
openaire +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Deciphering Seed Sequence Based Off-Target Effects in a Large-Scale RNAi Reporter Screen for E-Cadherin Expression. [PDF]
PLoS ONE, 2015 Functional RNAi based screening is affected by large numbers of false positive and negative hits due to prevalent sequence based off-target effects.
Robert Adams +3 more
doaj +1 more source