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Familial Adenomatous Polyposis
The American Journal of the Medical Sciences, 2020Familial adenomatous polyposis is a hereditary polyposis syndrome characterized by colorectal polyposis and eventually cancer if untreated, as well as a variety of benign and malignant extra-colonic features. Genetic testing and counselling is crucial for patients.
Abhishek Bhurwal +2 more
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Familial Adenomatous Polyposis
The American Journal of Gastroenterology, 2006Familial adenomatous polyposis (FAP) is an autosomal-dominant colorectal cancer syndrome, caused by a germline mutation in the adenomatous polyposis coli (APC) gene, on chromosome 5q21. It is characterized by hundreds of adenomatous colorectal polyps, with an almost inevitable progression to colorectal cancer at an average age of 35 to 40 yr ...
Polymnia, Galiatsatos +1 more
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Familial Adenomatous Polyposis
Seminars in Colon and Rectal Surgery, 2004Familial adenomatous polyposis is an inherited, autosomal-dominant syndrome that is caused by a germline mutation of the adenomatous polyposis gene (APC). The syndrome is characterized by the development of hundreds to thousands of adenomatous polyps in the colon and rectum with nearly all patients developing colorectal cancer if prophylactic surgery ...
Roberta L. Muldoon, Jennifer K. Lowney
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Familial adenomatous polyposis
Seminars in Surgical Oncology, 2000Familial adenomatous polyposis (FAP) is a dominantly inherited familial cancer syndrome characterized by an increased predisposition to colorectal cancer and other benign and malignant extra-colonic lesions. FAP has been linked to germline mutations of the adenomatous polyposis coli (APC) gene that encodes a protein with 2,843 amino acids that has ...
G, Lal, S, Gallinger
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Familial juvenile adenomatous polyposis
Journal of Pediatric Surgery, 1976Most colonic polyps in children are of the juvenile type and occur either as single or scattered colonic polyps. The peak incidence occurs between 4 and 6 yr of age, with a spontaneous decline from 12 to 15 yr. Significant clinical symptoms are rare, and operative therapy is rarely indicated.
F T, Velcek +5 more
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Familial adenomatous polyposis
Cancer, 1997BACKGROUND. Familial adenomatosis polyposis (FAP) is a prototype model for hereditary cancer. The adenomatous polyposis coli (APC) germline mutation, when identified within an FAP family, provides a powerful basis for early diagnosis. Indeed, the location of intragenic mutations in this large APC gene may distinguish the attenuated FAP variant ...
Henry T. Lynch +4 more
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Familial Adenomatous Polyposis
Surgical Oncology Clinics of North America, 2007Patients with FAP are guaranteed to have one major abdominal surgery in their life. They are also subject to cancers and benign disorders in other organ systems, some of which can be life threatening. Steering a course through life while avoiding preventable disease and complications of treatment, and maintaining good quality of life is a challenge for
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Familial Adenomatous Polyposis
Journal of the Royal Society of Medicine, 1992Juan J. Nogueras +5 more
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