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Causes of Death in Familial Adenomatous Polyposis
Scandinavian Journal of Gastroenterology, 1999 The prognosis in familial adenomatous polyposis (FAP) has improved over the past decades owing to a reduction in the prevalence of colorectal cancer, resulting from effective early screening. During the same period several polyposis registers have recorded an increasing number of deaths due to duodenal/periampullary cancer and desmoid tumours.
Galle, T S +2 more
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Familial adenomatous polyposis
Seminars in Surgical Oncology, 2000Familial adenomatous polyposis (FAP) is a dominantly inherited familial cancer syndrome characterized by an increased predisposition to colorectal cancer and other benign and malignant extra-colonic lesions. FAP has been linked to germline mutations of the adenomatous polyposis coli (APC) gene that encodes a protein with 2,843 amino acids that has ...
G, Lal, S, Gallinger
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Familial Adenomatous Polyposis
The American Journal of Gastroenterology, 2006Familial adenomatous polyposis (FAP) is an autosomal-dominant colorectal cancer syndrome, caused by a germline mutation in the adenomatous polyposis coli (APC) gene, on chromosome 5q21. It is characterized by hundreds of adenomatous colorectal polyps, with an almost inevitable progression to colorectal cancer at an average age of 35 to 40 yr ...
Polymnia, Galiatsatos +1 more
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Familial Adenomatous Polyposis
Surgical Oncology Clinics of North America, 2007Patients with FAP are guaranteed to have one major abdominal surgery in their life. They are also subject to cancers and benign disorders in other organ systems, some of which can be life threatening. Steering a course through life while avoiding preventable disease and complications of treatment, and maintaining good quality of life is a challenge for
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The history of familial adenomatous polyposis
Familial Cancer, 2006The first convincing case of familial adenomatous polyposis was published 120 years ago, and in the first half of this period the disease was primarily described and managed by surgeons and pathologists. Since the discovery of the APC gene, familial adenomatous polyposis has changed into a disease, which is nowadays diagnosed, treated and controlled by
Bülow, Steffen, Berk, Terri, Neale, Kay
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Familial juvenile adenomatous polyposis
Journal of Pediatric Surgery, 1976Most colonic polyps in children are of the juvenile type and occur either as single or scattered colonic polyps. The peak incidence occurs between 4 and 6 yr of age, with a spontaneous decline from 12 to 15 yr. Significant clinical symptoms are rare, and operative therapy is rarely indicated.
F T, Velcek +5 more
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Operations for Familial Adenomatous Polyposis
Surgical Oncology Clinics of North America, 1996The purpose of this article is to discuss the advantages and disadvantages of surgical procedures designed to eliminate the risk of colorectal cancer, the surgical treatment of extracolonic polyps, and the management of desmoid tumors.
P M, Sagar, J H, Pemberton
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Hepatoblastoma and Familial Adenomatous Polyposis
JNCI Journal of the National Cancer Institute, 1988Eleven children have been identified as having hepatoblastoma and a family history of adenomatous polyposis, and 14 additional instances of this association have been collected from the literature. Among the 11 survivors of hepatoblastoma in the combined series, adenomatous lesions have been sought in seven and detected in six patients at ages 7 to 25 ...
J. E. Garber +10 more
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