Results 111 to 120 of about 3,303,931 (259)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Clinical Management of Familial Gastric Cancer

, 2013
The clinical management of familial gastric carcinoma requires a multidisciplinary counsel. In this chapter we discuss about the hereditary diffuse gastric cancer surveillance and other minor genetic diseases as the hereditary nonpolyposis colorectal ...
Marrelli D, Roviello F, Corso G
core   +1 more source

SV-MeCa: an XGBoost-based meta-caller approach for structural variant calling from short-read data

BMC Bioinformatics
Background Calling structural variants (SVs), i.e., genomic alterations of $$\ge $$ 50bp, from whole genome short-read data remains challenging, as existing callers are known to lack accuracy and robustness.
Rudel Christian Nkouamedjo Fankep, Arda Söylev, Anna-Lena Kobiela, Jochen Blom, Corinna Ernst, Susanne Motameny   +5 more
doaj   +1 more source

Intentions of Patients With Cancer and Their Relatives to Use a Live Chat on Familial Cancer Risk: Results From a Cross-Sectional Web-Based Survey. [PDF]

J Med Internet Res, 2023
Memenga P, Baumann E, Luetke Lanfer H, Reifegerste D, Geulen J, Weber W, Hahne A, Müller A, Weg-Remers S.   +8 more
europepmc   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Long-term yield of pancreatic cancer surveillance in high-risk individuals

, 2022
Objective: We aimed to determine the long-term yield of pancreatic cancer surveillance in hereditary predisposed high-risk individuals. Design: From 2006 to 2019, we prospectively enrolled asymptomatic individuals with an estimated 10% or greater ...
Dutch Familial Pancreatic Cancer Surveillance Study Group
core  

Long-Term Adaptation Among Adolescent and Young Adult Children to Familial Cancer Risk. [PDF]

Pediatrics, 2022
McDonnell GA, Peshkin BN, DeMarco TA, Peterson SK, Arun BK, Miesfeldt S, O'Neill SC, Schneider K, Garber J, Isaacs C, Luta G, Tercyak KP.   +11 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating the prevalence of pathogenic variants in Saudi Arabian patients with familial cancer using a multigene next generation sequencing panel. [PDF]

Oncotarget, 2023
AlHarbi M, Mobark NA, AlJabarat WAR, ElBardis H, AlSolme E, Hamdan AB, AlFakeeh AH, AlMushawah F, AlHarthi F, AlSharm AA, Balbaid AAO, AlJohani N, Zhou AY, Robinson HA, Alqahtani SA, Abedalthagafi M.   +15 more
europepmc   +1 more source