Results 71 to 80 of about 270,260 (303)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The awareness of novelty for strangely familiar words : a laboratory analogue of the déjà vu experience [PDF]

, 2014
Akira O’Connor is supported by a SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence) fellowship. Josephine Urquhart was supported by the University of St Andrews URIP Scheme.Déjà vu is a nebulous memory experience defined by a clash ...
Josephine A. Urquhart, O'Connor, Akira Robert, Akira R. O’Connor, Urquhart, Josephine   +3 more
core   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Speaker recognition based on auditory impression: The role of familiarity with the speaker and language [PDF]

NBP: Nauka, bezbednost, policija
Speech is a fundamental means of interpersonal communication. Speaker identification based on voice and speech can be analysed through two perspectives, expert listening by trained phoneticians, for the purpose of forensic speaker identification, and by ...
Šešum Mia, Drljan Bojana, Ivanović Maja, Arsenić Ivana   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Variation in Experience and Team Familiarity: Addressing the Knowledge Acquisition-Application Problem [PDF]

Prior work in organizational learning has failed to find a consistent effect of variation in experience on performance. While some studies find a positive relationship between these two variables, others find no effect or even a negative relationship. In
Bradley R. Staats, Robert S. Huckman
core  

Optimal learning rules for familiarity detection [PDF]

, 2008
It has been suggested that the mammalian memory system has both familiarity and recollection components. Recently, a high-capacity network to store familiarity has been proposed.
David C. Sterratt, Willshaw, David J., David I. Donaldson, Donaldson, David, Willshaw, David J, Van Rossum, Mark C.W., Rossum, Mark C. W., David J. Willshaw, Donaldson, David I., Mark C. W. van Rossum, van Rossum, Mark C W, Sterratt, David C, Sterratt, David C., Andrea Greve, Greve, Andrea   +14 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Neuroimaging Studies on Familiarity of Music in Children with Autism Spectrum Disorder [PDF]

, 2020
The field of music neuroscience allows us to use music to investigate human cognition in vivo. Examining how brain processes familiar and unfamiliar music can elucidate underlying neural mechanisms of several cognitive processes.
De Barros Freitas, Carina Patricia, Freitas, Carina Patrícia de Barros   +1 more
core