Results 81 to 90 of about 270,260 (303)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Viewers base estimates of face matching accuracy on their own familiarity: Explaining the photo-ID paradox [PDF]

, 2015
Matching two different images of a face is a very easy task for familiar viewers, but much harder for unfamiliar viewers. Despite this, use of photo-ID is widespread, and people appear not to know how unreliable it is.
Ritchie, Kay, Bindemann, Markus, Burton, A. Mike, Jenkins, Rob, Smith, Finlay, Smith, Finlay G., White, David, Ritchie, Kay L.   +7 more
core   +1 more source

Familiarity-taxis: a bilateral approach to view-based snapshot navigation

Many insects use view-based navigation, or snapshot matching, to return to familiar locations, or navigate routes. This relies on egocentric memories being matched to current views of the world.
Thomas Nowotny (146275), Alex Dewar (17207131), Paul Graham (4460806), Andy Philippides (4461394), Fabian Steinbeck (14138814), Efstathios Kagioulis (17819933)   +5 more
core   +1 more source

Being-with: A study of familiarity [PDF]

Interacting with Computers, 2008
How people learn to use an interactive device has always been an important field of research in human-computer interaction (HCI). The theoretical bases of which have ranged from the traditional cognitive perspectives through situated learning to collectivist - social perspectives.
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Characterizing Episodic Memory Retrieval: Electrophysiological Evidence for Diminished Familiarity following Unitization [PDF]

, 2012
Episodic memory relies on both recollection and familiarity; why these processes are differentially engaged during retrieval remains unclear. Traditionally, recollection has been considered necessary for tasks requiring associative retrieval, whereas ...
Murray, Jamie, Donaldson, David, Pilgrim, Lea, Murray, Jamie G., Donaldson, David I., Pilgrim, Lea K., Pilgrim, Lesley Karen   +6 more
core   +1 more source

Kin recognition in three samples of Phytoseiulus persimilis (Acari: Phytoseiidae)

Persian Journal of Acarology, 2013
Kin recognition as an important phenomenon which influences species fitness is mediated by mechanisms such as association or familiarity. Here, we have investigated either prior association or relatedness would affect the predatory mite, Phytoseiulus ...
Abolfazl Zeraatkar, Azadeh Zahedi Golpayegani, Alireza Saboori   +2 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source