Results 91 to 100 of about 596 (266)

Ole Christensen & Birgitte Tufte: Familier i forandring - hverdag og medier i danske familier

open access: yesMedieKultur: Journal of Media and Communication Research, 2003
Bent Steeg Larsen
doaj   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

O ensino do léxico: As expressões idiomáticas

open access: yesTrabalhos em Linguística Aplicada, 2012
Cet article a l'intention de contribuer à l'enseignement d'un secteur très spécial du lexique, étant donné sa haute fréquence dans l'usage familier de n'importe quelle langue.
Cláudia Maria Xatara
doaj  

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Familier og forældreskaber anno 2014

open access: yesKvinder, Køn & Forskning, 2014
Catrine Andersson   +2 more
doaj   +1 more source

La réalité sociale : structure et qualité.

open access: yesEspacesTemps.net, 2010
Les deux philosophes Pierre Livet et Frédéric Nef, le premier proche et familier de la sociologie pragmatique, le second célèbre pour son œuvre de métaphysicien, élaborent dans cet ouvrage une ontologie de la réalité sociale, qu’ils présentent sous l ...
Nina Schmidt
doaj  

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