Results 81 to 90 of about 985,306 (254)

Pengaruh Dukungan Supervisor Terhadap Work Family Conflict

open access: yesWacana: Jurnal Sosial dan Humaniora, 2016
Penelitian empiris di bidang work family conflict (konflik antara kerja dan keluarga) menunjukkan bahwa work family conflict memiliki dampak yang negatif terhadap individu, keluarga dan organisasi.
Wike Wike   +3 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

The integrative relationship between work–family conflict and turnover intention: a meta-analysis

open access: yesFrontiers in Public Health
The impact of work–family conflict on employee turnover intention has become a significant topic in organizational behavior research. However, existing findings show significant discrepancies, lacking systematic quantitative integration.
Guanghua Li   +5 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

THE DETERMINANTS OF FAMILY WORK CONFLICTS IN SMALL AND MEDIUM-SIZED ENTREPRISES

open access: yes
This paper aims to analyze the determinants factors of the conflict between work and family life of women in Cameroonian enterprises. We use models to explain conflict situations, the main antecedents of which are both social and family-based.  The survey was conducted among 408 women in companies located in several regions of the country.
FEHNUI Elvine TAPEY   +2 more
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Predicting Work-Family and Familywork Conflict from Work and Family Domain: A Longitudinal Study

open access: yesInternational Journal of Management Studies, 2012
Although work-family conflict studies are available in Malaysia, most rely on cross-sectional design and focus on women. This study uses the longitudinal design on a heterogeneous sample which is aimed to enhance the understanding of the antecedents of ...
Zaiton Hassan, Hana Hamidi
doaj  

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