Results 81 to 90 of about 2,573,215 (300)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Work-Family Conflict Impact on Psychological Safety and Psychological Well-Being: A Job Performance Model

open access: yesFrontiers in Psychology, 2020
In a modern working environment characterized by new technology and work assignments extended to personal time, employees are expected to balance multiple roles while maintaining maximum productivity.
Bojan Obrenovic   +3 more
doaj   +1 more source

Family-friendly policies for rural working mothers [PDF]

open access: yes, 2009
For working parents, family friendly work policies like paid sick days, flexible time, or medical insurance can reduce work-family conflict and lead to less absenteeism and higher productivity.
Glauber, Rebecca K.
core   +1 more source

The mediating role of work-family conflict in the relationship between supervisor support and job satisfaction [PDF]

open access: yes, 2010
With the increase in single mother employees, there has been an increased concern over the work-family conflict that they experience in trying to balance the demands of work and family roles. Recognizing the impact of the conflict on job satisfaction and
Ahmad, Aminah   +3 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

WORK FAMILY CONFLICT - KONFLIK PERAN GANDA PADA PRAMUDI BIS WANITA [PDF]

open access: yes, 2016
Penelitian ini bertujuan untuk mengetahui gambaran konflik kerja khususnya Work Family Conflict pada pengemudi bis wanita Transjakarta. Penelitian dilakukan pada tiga subjek yang merupakan Pramudi wanita Transjakarta.
Putri, Ainindiya Dinanti
core  

Work-Family Conflict and Family-Work Conflict on Employees Turnover Intentions in the Tourism Industry

open access: yesInternational Journal of Heritage, Tourism and Hospitality, 2018
Work Family Conflict (WFC) happens when work weights meddle with the nature of family life, though Family Work Conflict (FWC) happens when family weights meddle with obligations at work. Then again, Turnover Intention (TOI) is about deliberate or involuntary act of quitting their job (Lingard & Valerie, 2009).
openaire   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Relationships between Time Management, Control, Work–family Conflict, and Strain [PDF]

open access: yes, 1999
This article incorporates recent research regarding time management into a model of work–family conflict. The authors hypothesized that 3 types of time management behavior would have both direct and indirect (through perceived control of time ...
Adams, Gary A., Jex, Steve M.
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

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