Results 21 to 30 of about 59,688 (255)

Socio-economic perspectives of family farming in South America: cases of Bolivia, Colombia and Peru

open access: yesAgronomía Colombiana, 2014
Family farming is very important because it is, among other types, the principal source of food and employment, especially in developing countries. Given the constant changes in the agrarian structure and environment, what are the prospects of family ...
Juan Carlos Barrientos-Fuentes   +1 more
doaj   +1 more source

Family Farming and the Worlds to Come [PDF]

open access: yes, 2015
What is family farming? How can it help meet the challenges confronting the world? How can it contribute to a sustainable and more equitable development? Not only is family farming the predominant form of agriculture around the world, especially so in developing countries, it is also the agriculture of the future.
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Challenges for a Transition from Peasant Agriculture to a Business Agriculture in Burkina Faso

open access: yesTurkish Journal of Agriculture: Food Science and Technology, 2018
Since the national farmers' day on May 12, 2017 in Kaya, Burkina Faso, the debate on agriculture has been to establish the agricultural entrepreneurship through the concept of agriculture as a family business (ACEF).
Babou Sogue, Handan Akçaöz
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Agroecological family farming in Uruguay, innovative and counter-hegemonic contributions to sustainability

open access: yesAgrociencia Uruguay
Agroecological family farming in Uruguay has a background of over thirty years and is increasingly recognized as a valid option for the transformation of the food system. However, basic and comprehensive information on the sector is not available.
Alberto Gómez Perazzoli   +2 more
doaj   +1 more source

MOTIVASI PETANI DALAM MEMPERTAHANKAN SISTEM TRADISIONAL PADA USAHATANI PADI SAWAH DI DESA PARBAJU JULU KABUPATEN TAPANULI UTARA PROPINSI SUMATERA UTARA

open access: yesJurnal Agrisep, 2011
This research aims to identify factors correlated significantly to the motivation of farmers in perseving traditional rainfed farming systems, such as using local seeds and planting once a year.
Reflis Reflis   +2 more
doaj   +1 more source

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